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ChemicalBook >> CAS DataBase List >>Amuvatinib

Amuvatinib

CAS No.
850879-09-3
Chemical Name:
Amuvatinib
Synonyms
AMuvatinib;Mp470;HPK 56;CS-460;MP470;HPK 56;MP-470(MP 470);AMuvatinib (MP-470);MP-470 (Amuvatinib);MP470 AMUVATINIB (MP-470);Amuvatinib, 10 mM in DMSO
CBNumber:
CB02484967
Molecular Formula:
C23H21N5O3S
Molecular Weight:
447.51
MDL Number:
MFCD16038298
MOL File:
850879-09-3.mol
Last updated:2024-11-17 16:00:36

Amuvatinib Properties

Density 1.443
storage temp. Store at -20°C
solubility ≥22.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form solid
color White to off-white
CAS DataBase Reference 850879-09-3
NCI Dictionary of Cancer Terms amuvatinib; MP470
FDA UNII SO9S6QZB4R
NCI Drug Dictionary amuvatinib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

Amuvatinib price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21461 Amuvatinib ≥98% 850879-09-3 1mg $110 2024-03-01 Buy
Cayman Chemical 21461 Amuvatinib ≥98% 850879-09-3 5mg $218 2024-03-01 Buy
Cayman Chemical 21461 Amuvatinib ≥98% 850879-09-3 10mg $380 2024-03-01 Buy
Cayman Chemical 21461 Amuvatinib ≥98% 850879-09-3 25mg $812 2024-03-01 Buy
TRC A822578 Amuvatinib 850879-09-3 5mg $335 2021-12-16 Buy
Product number Packaging Price Buy
21461 1mg $110 Buy
21461 5mg $218 Buy
21461 10mg $380 Buy
21461 25mg $812 Buy
A822578 5mg $335 Buy

Amuvatinib Chemical Properties,Uses,Production

Description

Amuvatinib (also known as MP-470 or 850879-09-3), is a multi-targeted inhibitor of receptor tyrosine kinases that inhibits c-Kit, platelet-derived growth factor receptor α (PDGFRα), and c-Met (IC50s = 10, 40, and 81 nM, respectively). It inhibits growth and induces apoptosis in prostate cancer cell lines, with additive effects achieved when combined with erlotinib . Amuvatinib sensitizes cancer cells to radiation and chemotherapeutic compounds, in part by inhibiting homologous recombination.

Uses

MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

Definition

ChEBI: N-(1,3-benzodioxol-5-ylmethyl)-4-(4-benzofuro[3,2-d]pyrimidinyl)-1-piperazinecarbothioamide is a N-arylpiperazine.

Clinical Use

Amivantamab is the first drug approved by the FDA for the treatment of patients with NSCLC and EGFR exon 20 insertion mutations.

target

c-KitD816H

Mode of action

Μechanisticly, amuvatinib inhibits tyrosine kinase receptor KIT through occupying its ATP binding domain (IC50 < 0.1 μM) and disrupts DNA repair through suppression of homologous recombination protein Rad51 as well as synergistic effects in combination with double stranded DNA damaging agents.

References

1. Effects of combining amuvatinib (MP-470) with DNA-damaging agents in osteosarcoma cell lines
2. Janssen submits supplemental biologics license application to the U.S. Food and Drug Administration seeking approval of RYBREVANT? (amivantamab-vmjw) in combination with chemotherapy for the first-line treatment of patients with locally advanced or metastatic EGFR exon 20 insertion mutation-positive non-small cell lung cancer. News release.
3. Raoul Tibes, Gil Fine, Gavin Choy, Sanjeev Redkar, Pietro Taverna, Aram Oganesian, Amarpao Sahai, Mohammad Azab and Anthony W. Tolcher. A phase I, first-in-human dose-escalation study of amuvatinib, a multi-targeted tyrosine kinase inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol (2013) 71: 463-471
4. Gavin Choy, Rajashree Joshi-Hangal, Aram Oganesian, Gil Fine, Scott Rasmussen, Joanne Collier, James Kissling, Amarpal Sahai, Mohammad Azab and Sanjeev Redkar. Saftety, tolerability, and pharmacokinetics of amuvatinib from three phase 1 clinical studies in healthy volunteers. Cancer Chemother Pharmacol (2012) 70: 183-190

Amuvatinib Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 142)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29865 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22787 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9718 58

View Lastest Price from Amuvatinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Amuvatinib pictures 2024-11-17 Amuvatinib
850879-09-3
 US $44.00-93.00 / mg 99.54% 10g TargetMol Chemicals Inc.
N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide pictures 2019-07-06 N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide
850879-09-3
 US $500.00 / KG 1KG 98% 100kg Career Henan Chemical Co
  • Amuvatinib pictures
  • Amuvatinib
    850879-09-3
  • US $44.00-93.00 / mg
  • 99.54%
  • TargetMol Chemicals Inc.
N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide 1-Piperazinecarbothioamide, N-(1,3-benzodioxol-5-ylmethyl)-4-benzofuro(3,2-D)pyrimidin-4-yl- HPK 56 MP-470(MP 470) AMuvatinib (MP-470) AMuvatinib (MP-470, HPK 56) MP470 AMUVATINIB (MP-470) MP 470 N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide Amuvatinib(MP470 ) N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro-[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioam N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide AMUVATINIB (MP-470);MP-470; MP 470; MP470; HPK 56 N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide USP/EP/BP MP470;HPK 56 MP-470; MP 470; MP470; HPK 56 MP-470 (Amuvatinib) CS-460 MP470 (MP-470, Amuvatinib) Mp470 AMuvatinib Amuvatinib, 10 mM in DMSO 850879-09-3 Inhibitors Inhibitor