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6-Nitroveratrumaldehyd

6-Nitroveratraldehyde Struktur
20357-25-9
CAS-Nr.
20357-25-9
Bezeichnung:
6-Nitroveratrumaldehyd
Englisch Name:
6-Nitroveratraldehyde
Synonyma:
DMNB;NVAD;NVAD20357-25-9;ASISCHEM R27925;DNA-K Inhibitor;6-nitroveratrol;DNA-PK Inhibitor;TIMTEC-BB SBB000505;6-NITROVERATRALDEHYDE;6-Nitroveratrumaldehyd
CBNumber:
CB4275729
Summenformel:
C9H9NO5
Molgewicht:
211.17
MOL-Datei:
20357-25-9.mol

6-Nitroveratrumaldehyd Eigenschaften

Schmelzpunkt:
131-133 °C (lit.)
Siedepunkt:
350.84°C (rough estimate)
Dichte
1.4194 (rough estimate)
Brechungsindex
1.5700 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
L?slichkeit
DMSO: 22 mg/mL
Aggregatzustand
solid
Farbe
yellow
Wasserl?slichkeit
Insoluble in water. Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO.
Sensitive 
Air & Light Sensitive
BRN 
395599
CAS Datenbank
20357-25-9(CAS DataBase Reference)
NIST chemische Informationen
6-Nitroveratraldehyde(20357-25-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
S-S?tze: 24/25
WGK Germany  3
RTECS-Nr. GY8410000
HazardClass  IRRITANT
HS Code  29130000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

6-Nitroveratrumaldehyd Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

yellow fluffy powder

Verwenden

6-Nitroveratraldehyde has been used in the preparation of no-carrier-added 6-18F-fluoro-L-dopa, fundamental tracer for cerebral positron emission tomography studies of dopaminergic system in humans and o-nitroaryl-bis(5-methylfur-2-yl)methanes, versatile synthons for the synthesis of nitrogen-containing heterocycles. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair. It is also used for synthesizing analogs of alpha-asarone.

Allgemeine Beschreibung

A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 μM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.

Biologische Aktivit?t

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC 50 = 15 μ M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

l?uterung methode

The aldehyde is purified by dissolving 9g in 200mL of boiling 95% EtOH, and set aside overnight to crystallise. It is then dried in vacuo at 50o and recrystallised from 110mL of 95% EtOH to give 6-7g of aldehyde with m 132-133o. Crystallisation from aqueous EtOH provides light yellow needles. It is light sensitive and should be stored in the dark [Fetscher Org Synth Coll Vol 4 735 1963]. [Beilstein 8 H 262, 8 I 610, 8 II 290, 6 III 2065, 6 IV 1785.]

6-Nitroveratrumaldehyd Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Benzenemethanamine, 4,5-dimethoxy-2-nitro- 4-hydroxy-5-methoxy-2-nitrobenzaldehyde 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE 6-Nitroveratrumylalkohol Veratrumaldehyd Toluol-4-thiol Vanillin Essigsure

Downstream Produkte

Benzene,1-[(4-methylphenyl)thio]-2,4-dinitro- 4,5-Dimethoxyanthranilsure 4-Chloro-6,7-dimethoxyquinazoline Methanol Acetamid 6,7-Dimethoxy-quinoline-2-carboxylic acid

6-Nitroveratrumaldehyd Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 299)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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CONIER CHEM AND PHARMA LIMITED 		+8618523575427
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20357-25-9(6-Nitroveratrumaldehyd)Verwandte Suche:

  • TIMTEC-BB SBB000505
  • ASISCHEM R27925
  • DMNB
  • 3,4-DIMETHOXY-6-NITROBENZALDEHYDE
  • 2-Nitro-4,5-dimethoxybenzaldehyde
  • 2-NITRO-4,5-BIS(METHYLOXY)BENZALDEHYDE
  • Benzaldehyde, 4,5-dimethoxy-2-nitro-
  • 6-NITROVERATRALDEHYDE
  • 4,5-DIMETHOXY-2-NITROBENZALDEHYDE
  • 4,5-DIMETHOXY-6-NITROBENZALDEHYDE
  • 6-NITROVERATRALDEHYDE, TECH., 80%
  • 6-NITROVERATRALDEHYDE 80%
  • 6-Nitro-3,4-dimethoxybenzaldehyde
  • 6-Nitroveratraldehyde, 4,5-Dimethoxy-2-formylnitrobenzene
  • 6-Nitroveratraldehyde, tech., 85% 25GR
  • 3,4-Dimethoxy-6-nitrobenzaldehyde, 6-Nitroveratraldehyde, DMNB
  • DNA-K Inhibitor
  • 6-Nitroveratraldehyde, 85%,tech
  • DNA-PK Inhibitor
  • DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem
  • 5-dimethoxy-2-nitrobenzaldehyde
  • NVAD
  • NVAD20357-25-9
  • 6-Nitroveratraldehyde>
  • 6-Nitroveratraldehyde ISO 9001：2015 REACH
  • 6-Nitroveratrumaldehyd
  • 6-nitroveratrol
  • 20357-25-9
  • O2NC6H234OCH32CHO
  • ALDEHYDE
  • C9
  • Cell Biology
  • Carbonyl Compounds
  • Cell Signaling and Neuroscience
  • Building Blocks
  • BioChemical
  • Kinase/Phosphatase Biology
  • Organic Building Blocks
  • Serine/Threonine Kinase Inhibitors
  • DNA-dependent protein kinase (DNA-PK)
  • Aldehydes
  • Aromatic Aldehydes & Derivatives (substituted)
  • Benzaldehyde
  • Aldehydes
  • C9
  • Carbonyl Compounds
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