NHC-triphosphate
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- CAS號(hào):
- 34973-27-8
- 英文名:
- NHC-triphosphate
- 英文別名:
- NHC-triphosphate;NHC triphosphate,NHCtriphosphate;Uridine 5'-(tetrahydrogen triphosphate), 4-oxime;N-HYDROXYCYTIDINE 5'-(TETRAHYDROGEN TRIPHOSPHONAT...;N4 Hydroxycytidine triphosphateQ: What is
N4 Hydroxycytidine triphosphate Q: What is the CAS Number of
N4 Hydroxycytidine triphosphate
- 中文名:
- NHC-triphosphate
- 中文別名:
- 化合物 T19476;化合物 NHC-TRIPHOSPHATE
- CBNumber:
- CB98054864
- 分子式:
- C9H16N3O15P3
- 分子量:
- 499.16
- MOL File:
- Mol file
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NHC-triphosphate化學(xué)性質(zhì)
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密度:
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2.52±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C, protect from light, stored under nitrogen
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酸度系數(shù)(pKa):
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0.97±0.50(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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水溶解性:
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Water: 160 mg/mL (320.54 mM)
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NHC-triphosphate性質(zhì)、用途與生產(chǎn)工藝
NHC-triphosphate 是 NHC (HY-125033) 的活性胞內(nèi)磷酸鹽代謝物 (intracellular metabolite ),以三磷酸鹽的形式存在。NHC-triphosphate 是病毒聚合酶 (viral polymerase) 的弱底物替代物,會(huì)被并入 HCV 復(fù)制子 RNA 中。
In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM
3
H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono-, di-, and triphosphate forms, and
NHC-TP
reaches up to 71.12 pM after 8 hours.NHC-triphosphate (NHC-TP) (5-40 μM) absence leads to full-length polymerization products, it can be a weak alternative substrate. In addition, incorporation of NHC-TP instead of CTP increases the molecular weight of the polymerization product by 16 (one extra oxygen) for each event and an obvious electrophoretic shift is observed in cell-free HCV NS5B polymerization reactions.Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC. Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP) can be observed, while NHC-triphosphate (HY-135867) remains the most abundant metabolite.NHC-triphosphate (NHC-TP) metabolite may directly target the viral polymerase and behave as a nonobligate chain terminator.?It plays a prominent role in inhibiting early negative-strand RNA synthesis, either through chain termination or mutagenesis, which may in turn interfere with correct replicase complex formation.
NHC-triphosphate
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更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
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2023/03/20 | HY-135867 | NHC-triphosphate NHC-triphosphate | 34973-27-8 | 1 mg | 4800元 |
NHC-triphosphate
生產(chǎn)廠家
34973-27-8, NHC-triphosphate 相關(guān)搜索:
- 抑制劑
- 化合物 NHC-TRIPHOSPHATE
- 化合物 T19476
- 34973-27-8
- N-HYDROXYCYTIDINE 5'-(TETRAHYDROGEN TRIPHOSPHONAT...
- Uridine 5'-(tetrahydrogen triphosphate), 4-oxime
- NHC triphosphate,NHCtriphosphate
- N4 Hydroxycytidine triphosphateQ: What is
N4 Hydroxycytidine triphosphate Q: What is the CAS Number of
N4 Hydroxycytidine triphosphate
- NHC-triphosphate