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NHC-triphosphate

NHC-triphosphate, 34973-27-8, 結(jié)構(gòu)式
NHC-triphosphate
CAS號(hào):
34973-27-8
英文名:
NHC-triphosphate
英文別名:
NHC-triphosphate;NHC triphosphate,NHCtriphosphate;Uridine 5'-(tetrahydrogen triphosphate), 4-oxime;N-HYDROXYCYTIDINE 5'-(TETRAHYDROGEN TRIPHOSPHONAT...;N4 Hydroxycytidine triphosphateQ: What is N4 Hydroxycytidine triphosphate Q: What is the CAS Number of N4 Hydroxycytidine triphosphate
中文名:
NHC-triphosphate
中文別名:
化合物 T19476;化合物 NHC-TRIPHOSPHATE
CBNumber:
CB98054864
分子式:
C9H16N3O15P3
分子量:
499.16
MOL File:
Mol file

NHC-triphosphate化學(xué)性質(zhì)

密度:
2.52±0.1 g/cm3(Predicted)
儲(chǔ)存條件:
Store at -20°C, protect from light, stored under nitrogen
酸度系數(shù)(pKa):
0.97±0.50(Predicted)
形態(tài):
Solid
顏色:
White to off-white
水溶解性:
Water: 160 mg/mL (320.54 mM)
安全信息

NHC-triphosphate性質(zhì)、用途與生產(chǎn)工藝

生物活性

NHC-triphosphate 是 NHC (HY-125033) 的活性胞內(nèi)磷酸鹽代謝物 (intracellular metabolite ),以三磷酸鹽的形式存在。NHC-triphosphate 是病毒聚合酶 (viral polymerase) 的弱底物替代物,會(huì)被并入 HCV 復(fù)制子 RNA 中。

體外研究

In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3 H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono-, di-, and triphosphate forms, and NHC-TP reaches up to 71.12 pM after 8 hours.NHC-triphosphate (NHC-TP) (5-40 μM) absence leads to full-length polymerization products, it can be a weak alternative substrate. In addition, incorporation of NHC-TP instead of CTP increases the molecular weight of the polymerization product by 16 (one extra oxygen) for each event and an obvious electrophoretic shift is observed in cell-free HCV NS5B polymerization reactions.Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC. Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP) can be observed, while NHC-triphosphate (HY-135867) remains the most abundant metabolite.NHC-triphosphate (NHC-TP) metabolite may directly target the viral polymerase and behave as a nonobligate chain terminator.?It plays a prominent role in inhibiting early negative-strand RNA synthesis, either through chain termination or mutagenesis, which may in turn interfere with correct replicase complex formation.

NHC-triphosphate 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

NHC-triphosphate 試劑級(jí)價(jià)格

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS編號(hào)包裝價(jià)格
2023/03/20HY-135867NHC-triphosphate
NHC-triphosphate
34973-27-81 mg4800元

NHC-triphosphate 生產(chǎn)廠家

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北京索萊寶科技有限公司 010-50973130 4009686088 3193328036@qq.com 中國(guó) 29785 68
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34973-27-8, NHC-triphosphate 相關(guān)搜索:

  • 抑制劑
  • 化合物 NHC-TRIPHOSPHATE
  • 化合物 T19476
  • 34973-27-8
  • N-HYDROXYCYTIDINE 5'-(TETRAHYDROGEN TRIPHOSPHONAT...
  • Uridine 5'-(tetrahydrogen triphosphate), 4-oxime
  • NHC triphosphate,NHCtriphosphate
  • N4 Hydroxycytidine triphosphateQ: What is N4 Hydroxycytidine triphosphate Q: What is the CAS Number of N4 Hydroxycytidine triphosphate
  • NHC-triphosphate
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