頭孢來(lái)星
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- CAS號(hào):
- 3577-01-3
- 英文名:
- cefaloglycin
- 英文別名:
- Kafocin;Kefglycin;Lilly-39435;cefaloglycin;Cephaloglycin;Cefaloglycine;Cephaloglycin(anhydrous);FUBBGQLTSCSAON-PBFPGSCMSA-N;(6R,7R)-7-[(R)-2-Amino-2-phenylacetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- 中文名:
- 頭孢來(lái)星
- 中文別名:
- 頭孢來(lái)星;頭孢甘氨;7-(D-Α-氨基苯基乙酰胺基)頭孢烷酸
- CBNumber:
- CB8926010
- 分子式:
- C18H19N3O6S
- 分子量:
- 405.42
- MOL File:
- 3577-01-3.mol
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頭孢來(lái)星化學(xué)性質(zhì)
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熔點(diǎn):
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236.5°C (rough estimate)
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沸點(diǎn):
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217.4°C (rough estimate)
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密度:
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1.3328 (rough estimate)
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折射率:
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1.6390 (estimate)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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Aqueous Acid (Slightly), Methanol (Slightly, Heated)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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pKa 1.71(H2O t=25±2 I=0.1 ) (Uncertain);7.29(H2O t=25±2 I=0.1 ) (Uncertain)
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顏色:
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White to Pale Brown
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水溶解性:
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10.5g/L(25 ºC)
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穩(wěn)定性:
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Hygroscopic, Moisture Sensitive, Temperature Sensitive
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頭孢來(lái)星性質(zhì)、用途與生產(chǎn)工藝
頭孢來(lái)星僅供口服，但吸收不完全，優(yōu)點(diǎn)是對(duì)青霉素酶穩(wěn)定，但血藥濃度不及先鋒霉素Ⅰ和先鋒霉素Ⅱ，尿中濃度較高。
頭孢來(lái)星作用機(jī)理似青霉素G鈉，適用于A組、B組溶血性鏈球菌、肺炎球菌、對(duì)青霉素G敏感金葡菌等革蘭陽(yáng)性球菌所致的各種感染，如敗血癥、肺炎、腦膜炎、扁桃體炎、中耳炎、猩紅熱、丹毒、產(chǎn)褥熱等。也可用于治療草綠色鏈球菌和腸球菌感染性心內(nèi)膜炎；梭狀芽孢桿菌所致的破傷風(fēng)、氣性壞疽、炭疽、白喉、流行性腦脊髓膜炎、梅毒、淋病、鉤端螺旋體病?？咕V似先鋒霉素Ⅰ，具有對(duì)革蘭氏陽(yáng)性菌如耐青霉素的金葡菌、非溶血性鏈球菌、肺炎雙球菌及白喉?xiàng)U菌、大腸桿菌、肺炎桿菌、流感桿菌等的抗菌作用。但對(duì)綠膿桿菌、結(jié)核桿菌無(wú)效。其特點(diǎn)是耐青霉素酶，而且對(duì)多種藥物的耐藥菌都有效，可用于對(duì)青霉素過(guò)敏的患者。
頭孢來(lái)星臨床使用不廣，主要用于治療泌尿系感染，但效果不及氨芐青霉素和羧芐青霉素。
Cefaloglycin (Cephaloglycin) 是一種具有口服活性的腎毒性 β-內(nèi)酰胺類 (β-lactam) 頭孢菌素抗生素，具有抗菌活性。Cefaloglycin 對(duì)腸球菌以外的革蘭氏陽(yáng)性球菌 (Gram-Positive cocci) 有活性。Cefaloglycin 對(duì)線粒體底物的攝取和呼吸也具有毒性。
Cefaclor to be comparable to Cephaloglycin in terms of in vitro activity against
S. pyogenes
and somewhat superior to Cephalexin.
Respiration with and the uptake of succinate and ADP are measured in rabbit renal cortical mitochondria exposed for 2 to 6 h to 300 to 3,000 μg of Cefaloglycin (Cephaloglycin) per mL and then washed to remove the antibiotic. Cefaloglycin (Cephaloglycin) irreversibly reduces both respiration and succinate uptake. The pattern of in vitro injury of Cefaloglycin to mitochondrial substrate uptake and respiration evolves in a time-dependent and concentration-dependent manner.
類別
有毒物質(zhì)
毒性分級(jí)
中毒
急性毒性
腹腔-大鼠 LD50: 1300 毫克/公斤; 腹腔-小鼠 LD50: 1030 毫克/公斤
可燃性危險(xiǎn)特性
受熱分解有毒氧化氮、氧化硫氣體
儲(chǔ)運(yùn)特性
庫(kù)房通風(fēng)低溫干燥
滅火劑
二氧化碳、干粉、泡沫
頭孢來(lái)星
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
3577-01-3, 頭孢來(lái)星 相關(guān)搜索:
- 357-71-3
- 頭孢甘氨
- 7-(D-Α-氨基苯基乙酰胺基)頭孢烷酸
- 頭孢來(lái)星
- 3577-01-3
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-, (6R,7R)-
- FUBBGQLTSCSAON-PBFPGSCMSA-N
- (6R,7R)-7-[(R)-2-Amino-2-phenylacetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cephaloglycin
- cefaloglycin
- Cefaloglycine
- (6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-azanyl-2-phenyl-ethanoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- (6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- (6R,7R)-3-(acetoxymethyl)-7-[[(2R)-2-amino-2-phenyl-acetyl]amino]-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Lilly-39435
- Kefglycin
- Kafocin
- Cephaloglycin(anhydrous)