6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
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- CAS號(hào):
- 1644443-47-9
- 英文名:
- Autophinib
- 英文別名:
- CS-2834;Autophinib;Autophinib, 10 mM in DMSO;PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor;6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine;6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE;4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-
- 中文名:
- 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
- 中文別名:
- 化合物AUTOPHINIB;AUTOPHINIB,VPS34抑制劑;AUTOPHAGY抑制劑(AUTOPHINIB);化合物AUTOPHINIB,10 MM DMSO 溶液;6-氯-N-(5-甲基-1H-吡唑-3-基)-2-(4-硝基苯氧基)嘧啶-4-胺
- CBNumber:
- CB83344886
- 分子式:
- C14H11ClN6O3
- 分子量:
- 346.73
- MOL File:
- 1644443-47-9.mol
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6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE化學(xué)性質(zhì)
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沸點(diǎn):
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640.6±65.0 °C(Predicted)
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密度:
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1.547±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO:13.98(Max Conc. mg/mL);40.32(Max Conc. mM)
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形態(tài):
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A solid
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酸度系數(shù)(pKa):
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13.78±0.10(Predicted)
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顏色:
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Light yellow to yellow
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6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE性質(zhì)、用途與生產(chǎn)工藝
Autophinib是有效的自噬 (autophagy)抑制劑，在饑餓誘導(dǎo)的自噬試驗(yàn)和rapamycin誘導(dǎo)的自噬試驗(yàn)中，其IC50分別為90 nM和40 nM。它還是Vps34的抑制劑，IC50為19 nM。
| Target | Value |
Vps34
()
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19 nM
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Autophagy
(Rapamycin induced)
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40 nM
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Autophagy
(starvation-induced)
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90 nM
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在喂養(yǎng)和饑餓條件下，Autophinib抑制自噬體的積累，但不影響自噬體的數(shù)量。所以，Autophinib不是一種晚期自噬抑制劑，而是抑制自噬體的形成。Autophinib能夠靶向VPS34，但不靶向其他脂質(zhì)激酶如mTOR和TBK1。Autophinib可能是ATP競(jìng)爭(zhēng)性的，在細(xì)胞溶解產(chǎn)物中靶向VPS34、誘導(dǎo)相應(yīng)的細(xì)胞表型。
6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/02/08 | HY-101920 | 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
Autophinib | 1644443-47-9 | 2mg | 600元 |
| 2025/02/08 | HY-101920 | 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
Autophinib | 1644443-47-9 | 5mg | 900元 |
6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
生產(chǎn)廠家
1644443-47-9, 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 細(xì)胞生物學(xué)試劑
- 化合物AUTOPHINIB,10 MM DMSO 溶液
- AUTOPHINIB,VPS34抑制劑
- 化合物AUTOPHINIB
- 6-氯-N-(5-甲基-1H-吡唑-3-基)-2-(4-硝基苯氧基)嘧啶-4-胺
- AUTOPHAGY抑制劑(AUTOPHINIB)
- 1644443-47-9
- Autophinib, 10 mM in DMSO
- PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor
- 4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-
- CS-2834
- 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
- 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
- Autophinib