FCE 28654
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- CAS號:
- 169474-77-5
- 英文名:
- Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
- 英文別名:
- FCE 28654;Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
- 中文名:
- FCE 28654
- 中文別名:
- 化合物 T13262;化合物 FCE 28654
- CBNumber:
- CB83339727
- 分子式:
- C25H35N2O7P
- 分子量:
- 506.53
- MOL File:
- 169474-77-5.mol
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FCE 28654化學(xué)性質(zhì)
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密度:
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1.242±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系數(shù)(pKa):
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1.22±0.30(Predicted)
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FCE 28654性質(zhì)、用途與生產(chǎn)工藝
FCE 28654 是一種水溶的?；?COA: 膽固醇?；D(zhuǎn)移酶 (ACAT) 抑制劑，在兔主動(dòng)脈、腸和猴肝臟的微粒體中，抑制 ACAT 的活性，IC50 值分別為 2.55，1.08 和 5.69 μM。
IC50: 2.55 μM (ACAT, Rabbit aorta), 1.08 μM (ACAT, Rabbit intestine), 5.69 μM (ACAT, Monkey liver)
FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC
50
s of 2.55, 1.08 and 5.69 μM, respcetively.
FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma.
FCE 28654
上下游產(chǎn)品信息
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下游產(chǎn)品
169474-77-5, FCE 28654 相關(guān)搜索:
- 抑制劑
- 化合物 FCE 28654
- 化合物 T13262
- 169474-77-5
- FCE 28654
- Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-