ZCL278
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- CAS號(hào):
- 587841-73-4
- 英文名:
- 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide
- 英文別名:
- 278;CS-912;ZCL 278;NSC 42964;ZCL278, >95%;ZCL278, >=98%;ZCL278; ZCL-278;ZCL278, 10 mM in DMSO;CDC42 Inhibitor III, ZCL278 - CAS 587841-73-4 - Calbiochem;2-(4-Bromo-2-chlorophenoxy)-N-((4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)carbAmothioy
- 中文名:
- ZCL278
- 中文別名:
- ZCL 278,CDC42抑制劑;化合物ZCL 278,10 MM DMSO 溶液;2-(4-溴-2-氯苯氧基)-N-((4-(N-(4,6-二甲基嘧啶-2-基)氨磺?；?苯基)氨基硫代甲酰基)乙酰胺;2-(4-溴-2-氯苯氧基)-N-[[[4-[[(4,6-二甲基-2-嘧啶基)氨基]磺?；鵠苯基]氨基]硫代甲?；鵠乙酰胺
- CBNumber:
- CB82668761
- 分子式:
- C21H19BrClN5O4S2
- 分子量:
- 584.89
- MOL File:
- 587841-73-4.mol
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ZCL278化學(xué)性質(zhì)
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儲(chǔ)存條件:
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+2C to +8C
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溶解度:
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≥29.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
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形態(tài):
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Light beige solid
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顏色:
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White to light yellow
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ZCL278性質(zhì)、用途與生產(chǎn)工藝
ZCL278是一個(gè)選擇性的Cdc42 GTP酶抑制劑，Kd為11.4 μM。
ZCL278通過(guò)與GTP競(jìng)爭(zhēng)來(lái)抑制Cdc42 GTP酶的活性，在對(duì)Rac/Cdc42磷酸化的抑制上呈現(xiàn)時(shí)效性關(guān)系。 ZCL278 (50 μM)抑制Cdc42-介導(dǎo)的微突形成，破壞血清饑餓Swiss 3T3成纖維細(xì)胞中GM130連接的高爾基結(jié)構(gòu)。ZCL278還能夠抑制轉(zhuǎn)移性的前列腺癌細(xì)胞系PC-3中Cdc42介導(dǎo)的神經(jīng)元分支、生長(zhǎng)錐動(dòng)力學(xué)和肌動(dòng)蛋白介導(dǎo)的運(yùn)動(dòng)遷徙能力，并且沒(méi)有細(xì)胞毒性。
ZCL278
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/02/08 | HY-13963 | ZCL278 | 587841-73-4 | 5 mg | 723元 |
| 2025/02/08 | HY-13963 | ZCL278
ZCL278 | 587841-73-4 | 10mg | 1157元 |
587841-73-4, ZCL278 相關(guān)搜索:
- Inhibitors
- 抑制劑
- 藥靶配體
- 小分子抑制劑，天然產(chǎn)物
- 小分子抑制劑
- 化合物ZCL 278,10 MM DMSO 溶液
- ZCL 278,CDC42抑制劑
- 2-(4-溴-2-氯苯氧基)-N-((4-(N-(4,6-二甲基嘧啶-2-基)氨磺?；?苯基)氨基硫代甲?；?乙酰胺
- 2-(4-溴-2-氯苯氧基)-N-[[[4-[[(4,6-二甲基-2-嘧啶基)氨基]磺酰基]苯基]氨基]硫代甲?；鵠乙酰胺
- 587841-73-4
- ZCL278, 10 mM in DMSO
- NSC 42964
- 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide USP/EP/BP
- Acetamide, 2-(4-bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]-
- 278
- CDC42 Inhibitor III, ZCL278 - CAS 587841-73-4 - Calbiochem
- ZCL278; ZCL-278
- CS-912
- ZCL278, >95%
- ZCL278, >=98%
- 2-(4-Bromo-2-chlorophenoxy)-N-((4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)carbAmothioy
- ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
- 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
- ZCL 278
- 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide ZCL278
- 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide