YF-2 HYDROCHLORIDE
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- CAS號(hào):
- 1312005-62-1
- 英文名:
- YF-2
- 英文別名:
- YF-2;YF-2 hydrochloride;N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide:hydrochloride
- 中文名:
- YF-2 HYDROCHLORIDE
- 中文別名:
- CBNumber:
- CB82667683
- 分子式:
- C20H23Cl2F3N2O3
- 分子量:
- 467.31
- MOL File:
- 1312005-62-1.mol
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YF-2 HYDROCHLORIDE化學(xué)性質(zhì)
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形態(tài):
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Solid
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顏色:
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White to light yellow
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YF-2 HYDROCHLORIDE性質(zhì)、用途與生產(chǎn)工藝
YF-2 hydrochloride 是一種高度選擇性、可透過血腦屏障的組蛋白乙酰轉(zhuǎn)移酶 (histone acetyltransferase) 激動(dòng)劑，能夠在海馬區(qū)乙酰化 H3，對(duì) CBP，PCAF 和 GCN5 的 EC50 值分別為 2.75 μM，29.04 μM 和 49.31 μM，對(duì) HDAC 無作用。具有抗腫瘤和抗阿爾滋海默癥的活性。
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CBP
2.75 μM (EC
50
)
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PCAF
29.04 μM (EC
50
)
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GCN5
49.31 μM (EC
50
)
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YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells.
YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice.
YF-2 HYDROCHLORIDE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-16531A | YF-2 hydrochloride | | 1 mg | 772元 |
| 2024/11/08 | HY-16531 | YF-2 | | 1 mg | 665元 |
YF-2 HYDROCHLORIDE
生產(chǎn)廠家
1312005-62-1, YF-2 HYDROCHLORIDE 相關(guān)搜索:
- 抑制劑
- 1312005-62-1
- YF-2 hydrochloride
- N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide:hydrochloride
- YF-2