偽-HYDROXYLINOLEIC ACID
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- CAS號(hào):
- 57818-44-7
- 英文名:
- Voxilaprevir
- 英文別名:
- ABTL0812;ABTL 0812;ABTL-0812;ABTL0812
(ABTL 0812;α-Hydroxylinoleic acid;α-Hydroxylinoleic acid;2-hydroxylinoleic acid);ABTL 0812;2-HYDROXYLINOLEIC ACID;9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-;(9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid
- 中文名:
- 偽-HYDROXYLINOLEIC ACID
- 中文別名:
- Α-羥基油酸;Α-羥基油酸;化合物 T13430;偽-HYDROXYLINOLEIC ACID
- CBNumber:
- CB63160004
- 分子式:
- C18H32O3
- 分子量:
- 296.44
- MOL File:
- 57818-44-7.mol
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偽-HYDROXYLINOLEIC ACID化學(xué)性質(zhì)
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沸點(diǎn):
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409.7±30.0 °C(Predicted)
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密度:
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0.970±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/mL (16.87 mM)
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酸度系數(shù)(pKa):
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3.85±0.21(Predicted)
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形態(tài):
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Liquid
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顏色:
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Colorless to light yellow
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偽-HYDROXYLINOLEIC ACID性質(zhì)、用途與生產(chǎn)工藝
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) 可在肺鱗癌細(xì)胞系中通過(guò)誘導(dǎo)TRIB3的過(guò)表達(dá)和激活自噬來(lái)抑制 Akt/mTOR 軸。ABTL0812 還可誘導(dǎo) AMPK 激活和 ROS 積累。
| Target | Value |
Akt
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mTOR
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ABTL-0812 (ABTL0812; 10-100 μM; 48 hours) inhibits cell viability of squamous NSCLC H157 cells.
Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment.
Cell Viability Assay
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Cell Line:
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Human lung fibroblast MRC5 and squamous non-small cell lung (NSCLC) H157 cells
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Concentration:
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10, 30, 100 μM
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Incubation Time:
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48 hours
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Result:
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Inhibited cell viability of squamous NSCLC H157 cells, not lung fibroblast cell line MRC-5.
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ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts.
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively.
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Animal Model:
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Athymic female nude mice bearing MiaPaca2 and A549 xenograft models
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Dosage:
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120 mg/kg
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Administration:
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Administered by oral gavage; 5 times per week for 33 days
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Result:
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Induced ER stress in human lung and pancreatic xenografts.
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偽-HYDROXYLINOLEIC ACID
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2024/11/08 | HY-U00141 | ABTL-0812 | | 1 mg | 1704元 |
| 2024/11/08 | HY-U00141 | 偽-HYDROXYLINOLEIC ACID
ABTL-0812 | 57818-44-7 | 5mg | 3750元 |
偽-HYDROXYLINOLEIC ACID
生產(chǎn)廠家
57818-44-7, 偽-HYDROXYLINOLEIC ACID 相關(guān)搜索:
- 抑制劑
- Α-羥基油酸
- 化合物 T13430
- Α-羥基油酸
- 偽-HYDROXYLINOLEIC ACID
- 57818-44-7
- α-Hydroxylinoleic acid
- 9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-
- ABTL 0812;2-HYDROXYLINOLEIC ACID
- (9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid
- ABTL0812
(ABTL 0812
- 2-hydroxylinoleic acid)
- α-Hydroxylinoleic acid
- ABTL-0812
- ABTL0812
- ABTL 0812