RNA Polymerase III Inhibitor
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- CAS號:
- 577784-91-9
- 英文名:
- RNA Polymerase III Inhibitor
- 英文別名:
- RNA Polymerase III Inhibitor;RNA Polymerase III Inhibitor inhibitor;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218
- 中文名:
- RNA Polymerase III Inhibitor
- 中文別名:
- 化合物ML-60218;2-氯-N-(3-(5-氯-3-甲基苯并[B]噻吩-2-基)-1-甲基-1H-吡唑-5-基)苯磺酰胺
- CBNumber:
- CB63136764
- 分子式:
- C19H15Cl2N3O2S2
- 分子量:
- 452.38
- MOL File:
- 577784-91-9.mol
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RNA Polymerase III Inhibitor化學性質(zhì)
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儲存條件:
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= -70C
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溶解度:
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Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
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形態(tài):
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Off-white solid
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顏色:
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Off-white
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穩(wěn)定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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RNA Polymerase III Inhibitor性質(zhì)、用途與生產(chǎn)工藝
ML-60218 是一種廣譜 RNA pol III 抑制劑，對釀酒酵母和人類 RNA pol III 的 IC50 分別為 32 和 27 μM。ML-60218 破壞已經(jīng)組裝好的病毒體，并且在不需要重新轉(zhuǎn)錄細胞 RNA 的情況下阻礙新病毒體的形成。
Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest.
In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation.
RNA Polymerase III Inhibitor
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
RNA Polymerase III Inhibitor
生產(chǎn)廠家
577784-91-9, RNA Polymerase III Inhibitor 相關搜索:
- 抑制劑
- 2-氯-N-(3-(5-氯-3-甲基苯并[B]噻吩-2-基)-1-甲基-1H-吡唑-5-基)苯磺酰胺
- 化合物ML-60218
- 577784-91-9
- 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide
- RNA Polymerase III Inhibitor inhibitor
- transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218
- Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-
- RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
- InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
- 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide
- RNA Polymerase III Inhibitor