Y320
|
|
|
- CAS號(hào):
- 288250-47-5
- 英文名:
- Y320
- 英文別名:
- Y320;Y320; Y 320;Y-320, >=98%;Y-320, 10 mM in DMSO;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami;1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLINOPIPERIDIN-1-YL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE;1-(4-chlorophenyl)-N-{3-cyano-4-[4-(morpholin-4-yl)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-
- 中文名:
- Y320
- 中文別名:
- 化合物Y320;化合物Y320,10 MM DMSO 溶液;1-(4-氯苯基)-N-(3-氰基-4-(4-嗎啉哌啶-1-基)苯基)-5-甲基-1H-吡唑-4-甲酰胺;1-(4-氯苯基)-N-[3-氰基-4-[4-(4-嗎啉基)-1-哌啶基]苯基]-5-甲基-1H-吡唑-4-甲酰胺
- CBNumber:
- CB62685328
- 分子式:
- C27H29ClN6O2
- 分子量:
- 505.01
- MOL File:
- 288250-47-5.mol
|
|
|
Y320化學(xué)性質(zhì)
-
沸點(diǎn):
-
631.2±55.0 °C(Predicted)
-
|
-
密度:
-
1.34±0.1 g/cm3(Predicted)
-
|
-
儲(chǔ)存條件:
-
2-8°C
-
|
-
溶解度:
-
≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
-
|
-
形態(tài):
-
solid
-
|
-
酸度系數(shù)(pKa):
-
11.82±0.70(Predicted)
-
|
-
顏色:
-
Off-white to pink
-
|
Y320性質(zhì)、用途與生產(chǎn)工藝
Y-320 是一種口服有效的 immunomodulator, 它通過(guò) CD4 T 細(xì)胞刺激 IL-15 從而抑制IL-17的產(chǎn)生，其IC50為20到60 nM。
Y-320通過(guò)被IL-15, CXCL12, 和anti-CD3 mAb刺激的小鼠CD4 T細(xì)胞也會(huì)抑制IFN-γ和TNF-α的產(chǎn)生。
Y-320 (0.3-3毫克/千克，口服)改善小鼠體內(nèi)膠原誘導(dǎo)性關(guān)節(jié)炎(CIA)，減少關(guān)節(jié)炎性關(guān)節(jié)中的IL-17 mRNA，并且在獼猴體內(nèi)表現(xiàn)出對(duì)CIA的治療作用。此外，Y-320與抗-TNF-α mAb結(jié)合在小鼠體內(nèi)表現(xiàn)出對(duì)慢性CIA的協(xié)同作用。
Y-320 是一種口服有效的 immunomodulator, 它通過(guò) CD4 T 細(xì)胞刺激 IL-15 從而抑制IL-17的產(chǎn)生，其IC50為20到60 nM。
Y-320通過(guò)被IL-15, CXCL12, 和anti-CD3 mAb刺激的小鼠CD4 T細(xì)胞也會(huì)抑制IFN-γ和TNF-α的產(chǎn)生。
Y-320 (0.3-3毫克/千克，口服)改善小鼠體內(nèi)膠原誘導(dǎo)性關(guān)節(jié)炎(CIA)，減少關(guān)節(jié)炎性關(guān)節(jié)中的IL-17 mRNA，并且在獼猴體內(nèi)表現(xiàn)出對(duì)CIA的治療作用。此外，Y-320與抗-TNF-α mAb結(jié)合在小鼠體內(nèi)表現(xiàn)出對(duì)慢性CIA的協(xié)同作用。
Y320
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/02/08 | HY-15898 | Y-320 | 288250-47-5 | 1 mg | 477元 |
| 2025/02/08 | HY-15898 | Y320
Y-320 | 288250-47-5 | 5mg | 1050元 |
288250-47-5, Y320 相關(guān)搜索:
- Inhibitors
- 抑制劑
- 藥靶配體
- 小分子抑制劑
- 小分子抑制劑，天然產(chǎn)物
- C27H29ClN6O2
- 化合物Y320,10 MM DMSO 溶液
- 化合物Y320
- 1-(4-氯苯基)-N-(3-氰基-4-(4-嗎啉哌啶-1-基)苯基)-5-甲基-1H-吡唑-4-甲酰胺
- 1-(4-氯苯基)-N-[3-氰基-4-[4-(4-嗎啉基)-1-哌啶基]苯基]-5-甲基-1H-吡唑-4-甲酰胺
- 288250-47-5
- Y-320, 10 mM in DMSO
- 1-(4-chlorophenyl)-N-{3-cyano-4-[4-(morpholin-4-yl)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide
- 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-
- Y320; Y 320
- 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami
- Y-320, >=98%
- Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
- 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320
- 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car
- 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
- 1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLINOPIPERIDIN-1-YL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
- Y320