4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
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- CAS號:
- 876708-03-1
- 英文名:
- RO 9187
- 英文別名:
- RO 9187;RO 9187;RO9187;2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-;4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2
(1H )-pyrimidinone;4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
- 中文名:
- 4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
- 中文別名:
- 化合物 T16774;化合物 RO-9187;4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
- CBNumber:
- CB62628361
- 分子式:
- C9H12N6O5
- 分子量:
- 284.22878
- MOL File:
- 876708-03-1.mol
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4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮化學(xué)性質(zhì)
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熔點:
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188.0-189.0℃
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儲存條件:
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Store at -20°C
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溶解度:
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H2O : 7.14 mg/mL (25.12 mM; Need ultrasonic)
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形態(tài):
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Powder
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顏色:
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Light yellow to yellow
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4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮性質(zhì)、用途與生產(chǎn)工藝
RO-9187是高效的HCV病毒復(fù)制抑制劑，IC50值為171 nM。
RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.
Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.
4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/02/08 | HY-10870 | 4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
RO-9187 | 876708-03-1 | 5mg | 2000元 |
| 2025/02/08 | HY-10870 | 4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
RO-9187 | 876708-03-1 | 10 mM * 1 mLin DMSO | 2200元 |
4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
生產(chǎn)廠家
876708-03-1, 4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮 相關(guān)搜索:
- 抑制劑
- 代謝
- 化合物 RO-9187
- 化合物 T16774
- 4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
- 876708-03-1
- 2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-
- 4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2
(1H )-pyrimidinone
- RO 9187;RO9187
- 4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
- RO 9187