9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
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- CAS號:
- 4551-00-2
- 英文名:
- 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
- 英文別名:
- NSC-70220;SOS1 inhibitor 1;NSC 70220,NSC70220;9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
- 中文名:
- 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
- 中文別名:
- 化合物 T12978;化合物 NSC-70220
- CBNumber:
- CB53221344
- 分子式:
- C22H15NO2
- 分子量:
- 325.36
- MOL File:
- 4551-00-2.mol
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9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-化學(xué)性質(zhì)
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熔點(diǎn):
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186 °C
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沸點(diǎn):
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569.6±49.0 °C(Predicted)
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密度:
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1.321±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C,unstable in solution, ready to use.
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溶解度:
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DMSO: 12.5 mg/mL (38.42 mM)
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形態(tài):
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Solid
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顏色:
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Light yellow to yellow
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9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-性質(zhì)、用途與生產(chǎn)工藝
NSC-70220 是一種選擇性的變構(gòu) SOS1 抑制劑。NSC-70220 抑制變構(gòu)位點(diǎn)激活，并部分抑制催化位點(diǎn)激活。NSC-70220 具有抗癌作用。
The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with NSC-70220 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of NSC-70220 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of NSC-70220 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of NSC-70220 overnight resulted in lower expression levels of P-ERK.
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2024/11/08 | HY-101796 | 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
NSC-70220 | 4551-00-2 | 5mg | 900元 |
| 2024/11/08 | HY-101796 | 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
NSC-70220 | 4551-00-2 | 10mg | 1500元 |
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
生產(chǎn)廠家
4551-00-2, 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]- 相關(guān)搜索:
- 抑制劑
- 化合物 NSC-70220
- 化合物 T12978
- 4551-00-2
- NSC 70220,NSC70220
- SOS1 inhibitor 1
- NSC-70220
- 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-