4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
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- CAS號:
- 6837-93-0
- 英文名:
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- 英文別名:
- NSC16168,NSC-16168;4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid;1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid;4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid;8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid;4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid;2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
- 中文名:
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- 中文別名:
- 化合物 T16351;化合物 NSC16168;4-氨基-5-(對甲苯磺酰氧基)萘-2,7-二磺酸
- CBNumber:
- CB4968018
- 分子式:
- C17H15NO9S3
- 分子量:
- 473.5
- MOL File:
- 6837-93-0.mol
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4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid化學(xué)性質(zhì)
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密度:
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1.5197 (rough estimate)
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折射率:
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1.7000 (estimate)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO: 31.25 mg/mL (66.00 mM)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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-1.16±0.40(Predicted)
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顏色:
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Off-white to gray
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4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid性質(zhì)、用途與生產(chǎn)工藝
NSC16168 是特異性 ERCC1-XPF 的抑制劑，其 IC50 值為0.42 μM。NSC16168 可抑制 DNA 修復(fù)，增強 CDDP 對癌癥的療效。
IC50: 0.42 μM (ERCC1-XPF).
NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.
Cell Viability Assay.
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Cell Line:
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H460 cells.
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Concentration:
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0-50 μM.
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Incubation Time:
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2 h.
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Result:
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Potentiated cisplatin efficacy in cancer cells.
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NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts.
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Animal Model:
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2.5×10
6
H460 cells were injected s.c. in the right flank of each mouse.
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Dosage:
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20 mg/kg.
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Administration:
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IP, twice daily for 10 days.
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Result:
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The tumor growth was minimally affected by compound and the mice displayed no signs of distress or toxic side effects.
The combination treatment with 16168 and cisplatin inhibited H460 tumor growth, which was maintained for the duration of the compound injections.
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類別
有毒物品
毒性分級
低毒
急性毒性
口服-大鼠LD50: 11500 毫克/公斤
刺激數(shù)據(jù)
眼睛-兔子100 毫克/24小時 重度
可燃性危險特性
可燃;燃燒產(chǎn)生有毒氮氧化物和硫氧化物煙霧
儲運特性
庫房通風(fēng)低溫干燥
滅火劑
干粉、泡沫、砂土、二氧化碳, 霧狀水
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
生產(chǎn)廠家
6837-93-0, 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid 相關(guān)搜索:
- 抑制劑
- 化合物 NSC16168
- 化合物 T16351
- 4-氨基-5-(對甲苯磺酰氧基)萘-2,7-二磺酸
- 6837-93-0
- NSC16168,NSC-16168
- 2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
- 4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid
- 8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid
- 4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid
- 1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid