2173232-79-4
|
|
|
- CAS號:
- 2173232-79-4
- 英文名:
- LOM612
- 英文別名:
- LOM612;LOM-612,LOM612;Naphth[2,3-d]isothiazole-4,9-dione, 3-(dimethylamino)-
- 中文名:
- 2173232-79-4
- 中文別名:
- 化合物 LOM612;化合物 T19405
- CBNumber:
- CB34797080
- 分子式:
- C13H10N2O2S
- 分子量:
- 258.3
- MOL File:
- 2173232-79-4.mol
|
|
|
2173232-79-4化學(xué)性質(zhì)
-
沸點(diǎn):
-
386.2±42.0 °C(Predicted)
-
|
-
密度:
-
1.436±0.06 g/cm3(Predicted)
-
|
-
儲(chǔ)存條件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 6 mg/mL (23.23 mM);Water : < 0.1 mg/mL (insoluble)
-
|
-
形態(tài):
-
Solid
-
|
-
酸度系數(shù)(pKa):
-
3.04±0.20(Predicted)
-
|
-
顏色:
-
Pink to red
-
|
2173232-79-4性質(zhì)、用途與生產(chǎn)工藝
LOM612 有效對 FOXO 胞質(zhì)-胞核穿梭進(jìn)行定位，在 U2fox RELOC 細(xì)胞中 EC50 值為 1.5 μM。
EC50: 1.5 μM (FOXO, in U2fox RELOC cells)
LOM612 potently activates nuclear translocation of FOXO with an EC
50
value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC
50
value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC
50
, 2.76 μM).
2173232-79-4
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-101035 | LOM612 | | 1 mg | 1590元 |
| 2024/11/08 | HY-101035 | 2173232-79-4
LOM612 | 2173232-79-4 | 5mg | 3500元 |
2173232-79-4, 2173232-79-4 相關(guān)搜索:
- 抑制劑
- 化合物 LOM612
- 化合物 T19405
- 2173232-79-4
- LOM-612,LOM612
- Naphth[2,3-d]isothiazole-4,9-dione, 3-(dimethylamino)-
- LOM612