TP0463518
|
|
|
- CAS號:
- 1558021-37-6
- 英文名:
- TP0463518
- 英文別名:
- BGE-117;TP0463518;HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors;Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-;2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
- 中文名:
- TP0463518
- 中文別名:
- 化合物TP0463518;2-(1-((6-(4-氯苯酚)吡啶-3-基)甲基)-4-羥基-2-氧代-1,2,5,6-四氫吡啶-3-甲酰胺)乙酸
- CBNumber:
- CB34656567
- 分子式:
- C20H18ClN3O6
- 分子量:
- 431.83
- MOL File:
- 1558021-37-6.mol
|
|
|
TP0463518化學(xué)性質(zhì)
-
沸點:
-
775.8±60.0 °C(Predicted)
-
|
-
密度:
-
1.512±0.06 g/cm3(Predicted)
-
|
-
儲存條件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO:40.0(Max Conc. mg/mL);92.63(Max Conc. mM)
-
|
-
形態(tài):
-
A solid
-
|
-
酸度系數(shù)(pKa):
-
3.63±0.10(Predicted)
-
|
-
顏色:
-
Light yellow to yellow
-
|
TP0463518性質(zhì)、用途與生產(chǎn)工藝
TP0463518 是一種有效的 hypoxia-inducible factor prolyl hydroxylases (PHDs) 的抑制劑，對人PHD2的Ki值為5.3 nM。TP0463518 還可抑制人PHD1、人PHD3和猴PHD2，對應(yīng)的IC50值分別為18 nM，63 nM和22 nM。
| Target | Value |
hPHD2
(Cell-free assay)
|
5.3 nM(Ki)
|
hPHD1
(Cell-free assay)
|
18 nM
|
monkey PHD2
(Cell-free assay)
|
22 nM
|
hPHD3
(Cell-free assay)
|
63 nM
|
TP0463518
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2024/11/08 | HY-112144 | TP0463518
TP0463518 | 1558021-37-6 | 5mg | 1800元 |
| 2024/11/08 | HY-112144 | TP0463518
TP0463518 | 1558021-37-6 | 10mM * 1mLin DMSO | 1980元 |
1558021-37-6, TP0463518 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 對照品
- 1558021-37-0
- 2-(1-((6-(4-氯苯酚)吡啶-3-基)甲基)-4-羥基-2-氧代-1,2,5,6-四氫吡啶-3-甲酰胺)乙酸
- 化合物TP0463518
- 1558021-37-6
- 2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
- HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors
- BGE-117
- Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-
- TP0463518