N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽
|
|
|
- CAS號:
- 53960-20-6
- 英文名:
- N-Methyl Trimetazidine Dihydrochloride
- 英文別名:
- Trimetazidine Impurity I;trimetazidine impurity1144;TriMetazidine EP IMpurity-I;Trimetazidine Impurity I HCl;Trimetazidine EP Impurity I DiHCl;1-Methyl-4-(2,3,4-trimethoxybenzyl);N-Methyl Trimetazidine Dihydrochloride;N-Methyl-trimetazidine dihydrochloride salt;Trimetazidine EP Impurity I(Dihydrochloride);Trimetazidine Impurity 9（Trimetazidine EP Impurity I)
- 中文名:
- N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽
- 中文別名:
- 曲美他嗪雜質(zhì)I;曲美他嗪EPI;曲美他嗪雜質(zhì)06;曲美他嗪雜質(zhì)1144;曲美他嗪雜質(zhì)I (EP);N-甲基曲美他嗪 鹽酸鹽;鹽酸曲美他嗪雜質(zhì)I(EP);曲美他嗪EP雜質(zhì)I DIHCL;曲美他嗪雜質(zhì)9(曲美他嗪EP雜質(zhì)I);N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽
- CBNumber:
- CB32510993
- 分子式:
- C15H24N2O3
- 分子量:
- 280.36266
- MOL File:
- 53960-20-6.mol
|
|
|
N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽化學(xué)性質(zhì)
-
熔點:
-
230℃ (decomposition)
-
|
-
儲存條件:
-
Refrigerator
-
|
-
溶解度:
-
DMSO (Slightly), Methanol (Slightly)
-
|
-
形態(tài):
-
Solid
-
|
-
顏色:
-
White to Off-White
-
|
-
InChI:
-
InChI=1S/C15H24N2O3/c1-16-7-9-17(10-8-16)11-12-5-6-13(18-2)15(20-4)14(12)19-3/h5-6H,7-11H2,1-4H3
-
|
-
InChIKey:
-
SQQDLCAQLUXIPC-UHFFFAOYSA-N
-
|
-
SMILES:
-
c1(OC)c(OC)c(CN2CCN(C)CC2)ccc1OC
-
|
N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
曲美他嗪雜質(zhì)I的合成如下：將N-甲基哌嗪溶于THF中，當(dāng)哌嗪完全溶解，滴加2,3,4-三甲氧基芐基氯，回流，攪拌混合物，冷卻，過濾。將濾液在旋轉(zhuǎn)蒸發(fā)器中濃縮，得曲美他嗪雜質(zhì)I。
雜質(zhì)的研究是藥品研發(fā)的一項重要內(nèi)容。它包括選擇合適的分析方法，準(zhǔn)確地分辨與測定雜質(zhì)的含量并綜合藥學(xué)、毒理及臨床研究的結(jié)果確定雜質(zhì)的合理限度。這一研究貫穿于藥品研發(fā)的整個過程。由于藥品在臨床使用中產(chǎn)生的不良反應(yīng)除了與藥品本身的藥理活性有關(guān)外，還與藥品中的雜質(zhì)有關(guān)。例如，青霉素等抗生素中的多聚物等高分子雜質(zhì)是引起過敏的主要原因。所以規(guī)范地進行雜質(zhì)的研究，并將雜質(zhì)控制在一個安全、合理的范圍之內(nèi)，將直接關(guān)系到上市藥品的質(zhì)量及安全性。曲美他嗪雜質(zhì)I可用于曲美他嗪研發(fā)過程中的標(biāo)準(zhǔn)制定中，在進行曲美他嗪仿制藥研發(fā)過程中，要對已上市的同品種產(chǎn)品的質(zhì)量進行詳細研究，分析其雜質(zhì)的種類包括曲美他嗪雜質(zhì)I及其含量，并與在研產(chǎn)品進行全面的質(zhì)量對比，據(jù)此再制訂出在研產(chǎn)品的雜質(zhì)限度，包括曲美他嗪雜質(zhì)I的限度。
N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽
生產(chǎn)廠家
53960-20-6, N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽 相關(guān)搜索:
鹽酸曲美他嗪 曲美他嗪雜質(zhì) 4-(2,3,4-三甲氧基芐基)-1-哌嗪甲醛鹽酸鹽 曲美他嗪雜質(zhì) 1-[(2,4,6-三甲氧基苯基)甲基]哌嗪二鹽酸鹽 丙二醇乙醚 甲氧芐啶雜質(zhì)I 2,3,4-三羥基苯甲醛 3-碘芐溴 甲氧芐啶雜質(zhì)C 2,3,4-三甲氧基苯乙酸 曲美他嗪雜質(zhì)F 2,3,4-三甲氧基苯甲醛 2,3,4-三甲氧基苯甲醇 曲美他嗪雜質(zhì)E 哌嗪 1-(3,4,5-三甲氧基芐基)哌嗪鹽酸鹽 曲美他嗪N-羧酸乙酯
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- 344-曲美他嗪
- 雜質(zhì)對照品
- 標(biāo)準(zhǔn)品
- 對照品-雜質(zhì)對照品
- C15H26Cl2N2O3
- 曲美他嗪雜質(zhì)06
- 曲美他嗪雜質(zhì)9(曲美他嗪EP雜質(zhì)I)
- 1-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽(曲美他嗪雜質(zhì))
- 曲美他嗪EPI
- 曲美他嗪雜質(zhì)1144
- N-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽
- 鹽酸曲美他嗪雜質(zhì)I(EP)
- 曲美他嗪EP雜質(zhì)I DIHCL
- 曲美他嗪雜質(zhì)I (EP)
- N-甲基曲美他嗪 鹽酸鹽
- 曲美他嗪雜質(zhì)I
- 1-甲基-4-(2,3,4-三甲氧基芐基)哌嗪二鹽酸鹽
- 53960-20-6
- Trimetazidine EP Impurity I(Dihydrochloride)
- 1-Methyl-4-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride (N-Methyltrimetazidine Dihydrochloride
- 1-methyl-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride? (Trimetazidine Impurity）
- 1-methyl-4-(2,3,4-trimethoxybenzyl)piperazine dihyrochloride
- Trimetazidine Dihydrochloride EP Impurity I as Dihydrochloride
- 1-methyl-4-(2,3,4-trimethoxybenzyl)piperazine (N-methyltrimetazidine)
- 1-Methyl-4-(2,3,4-trimethoxybenzyl)piperazine, hydrochloride (1:2)
- Trimetazidine Dihydrochloride Impurity IQ: What is
Trimetazidine Dihydrochloride Impurity I Q: What is the CAS Number of
Trimetazidine Dihydrochloride Impurity I Q: What is the storage condition of
Trimetazidine Dihydrochloride Impurity I
- trimetazidine impurity1144
- N-Methyl-trimetazidine dihydrochloride salt
- 1-Methyl-4-(2,3,4-trimethoxybenzyl)
- Trimetazidine Impurity I HCl
- Trimetazidine EP Impurity I DiHCl
- Trimetazidine Impurity 9（Trimetazidine EP Impurity I)
- 1-(2,3,4-Trimethoxybenzyl)-4-methylpiperazine dihydrochloride
- Trimetazidine Impurity I
- 1-Methyl-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
- TriMetazidine EP IMpurity-I
- 1-Methyl-4-[(2,3,4-triMethoxyphenyl)Methyl]piperazine Hydrochloride
- N-Methyl Trimetazidine Dihydrochloride