(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
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- CAS號:
- 91224-37-2
- 英文名:
- D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE
- 英文別名:
- SPANTIDE;SPANTIDE I;(D-Arg1,D-Trp7;SPANTIDE HYDROCHLORIDE;M.W. 1497.80 C75H108N20O13;1-Arg-7,9-Trp-11-Leu-substance p;(D-ARG1,D-TRP7,9,LEU11)-SUBSTANCE P;(D-Arg?,D-Trp?·?,Leu??)-Substance P;[D-Arg1,D-Trp7,9,L-Leu11]substance P;Substance p, Arg(1)-Trp(7,9)-Leu(11)-
- 中文名:
- (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
- 中文別名:
- 化合物 T20413;D-ARG1,D-TRP7,9,LEU11]神經(jīng)肽P物質(zhì)
- CBNumber:
- CB2230566
- 分子式:
- C75H108N20O13
- 分子量:
- 1497.79
- MOL File:
- 91224-37-2.mol
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(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P化學(xué)性質(zhì)
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密度:
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1.43±0.1 g/cm3(Predicted)
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儲存條件:
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−20°C
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形態(tài):
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Powder
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酸度系數(shù)(pKa):
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13.31±0.20(Predicted)
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顏色:
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White to off-white
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水溶解性:
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Soluble to 1 mg/ml in water
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(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P性質(zhì)、用途與生產(chǎn)工藝
Spantide I 是substance P 的類似物，是選擇性的神經(jīng)激肽-1 受體 (NK1 receptor) 的拮抗劑，其對NK1 和 NK2 受體的 Ki 值分別為 230 nM 和 8150 nM。Spantide I 可減少感染角膜的1型細胞因子和增強2型細胞因子 IL-10，從而顯著減少角膜穿孔。
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NK1
230 nM (Ki)
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NK2
8150 nM (Ki)
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Spantide I (50 and 100 nM perfused through the cerebral ventricles) causes a complete respiratory arrest in all of the examined animals.
Spantide I (36 μg/mouse, ip daily) significantly decreases the number of perforated corneas, bacterial counts, and PMNs. Spantide I also downregulates the mRNA levels for type I cytokines (e.g., IFN-γ) as well as MIP-2, IL-6, TNF-α, and IL-1β.
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Animal Model:
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Female, 8-week-old C57BL/6 (B6) and BALB/c mice.
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Dosage:
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36 μg/mouse.
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Administration:
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IP on days -1 and 0 (day of infection) and daily through 5 days pi (post infection).
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Result:
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At 3 and 5 days pi, compound-treated mice had significantly less severe ocular disease than did the PBS-treated mice.
Contained significantly fewer PMNs than the corneas of PBS-treated mice at 3 and 5 days pi.
Significantly reduced levels of corneal TNF-α mRNA at 3 and 5 days pi.
Significantly reduced the level of IL-18 mRNA at 1 day pi.
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(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2024/11/08 | HY-P1194 | (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
Spantide I | 91224-37-2 | 1 mg | 550元 |
| 2024/11/08 | HY-P1194 | (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
Spantide I | 91224-37-2 | 5 mg | 1650元 |
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
生產(chǎn)廠家
91224-37-2, (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P 相關(guān)搜索:
- Tachykinin receptor
- 藥靶配體
- 目錄肽
- 目錄多肽
- 標準品
- Tachykinins
- Peptides
- BioChemical
- Amino Acids and Peptides
- Biochemicals and Reagents
- Antagonist
- C75H108N20O13
- D-ARG1,D-TRP7,9,LEU11]神經(jīng)肽P物質(zhì)
- 化合物 T20413
- 91224-37-2
- (D-Arg?,D-Trp?·?,Leu??)-Substance P
- (D-Arg1,D-Trp7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
- SPANTIDE
- SPANTIDE I
- SPANTIDE HYDROCHLORIDE
- SUBSTANCE P, [D-ARG1, D-TRP7,9, LEU11]
- (D-Arg1,D-Trp7·9,Leu11)-Substance P, Spantide I
- (D-Arg1,D-Trp7
- Substance p, arginyl(1)-tryptophyl(7,9)-leucine(11)-
- Substance p, Arg(1)-Trp(7,9)-Leu(11)-
- Substance p, 1-D-arginine-7-D-tryptophan-9-D-tryptophan-11-D-leucine-
- L-Leucinamide, D-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-
- 1-Arg-7,9-Trp-11-Leu-substance p
- D-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2
- D-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2
- [D-Arg1,D-Trp7,9,L-Leu11]substance P
- M.W. 1497.80 C75H108N20O13
- D-ARG1,D-TRP7,9,LEU11]-SUBSTANCE P (SPANTIDE)
- (D-arg1,D-trp7,9,leu11)-substance P*acetate
- H-D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
- D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE
- D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
- (D-ARG1,D-TRP7,9,LEU11)-SUBSTANCE P
- [D-ARG1,D-TRP7,9,LEU11]-SUBSTANCE P HYDROCHLORIDE