鹽酸特拉唑嗪
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- CAS號:
- 109351-34-0
- 英文名:
- (R)-Terazosin
- 英文別名:
- (R)-Terazosin;Terazosin-002-R;(R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (R)-;Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2R)-tetrahydro-2-furanyl]-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI);(R)-Terazosin,α1-adrenoceptor,affinity,inhibit,subtypes,prove,Adrenergic Receptor,(R)Terazosin,Inhibitor,(R) Terazosin,Low,α2-adrenoceptor,Beta Receptor
- 中文名:
- 鹽酸特拉唑嗪
- 中文別名:
- (R)-特拉唑嗪;鹽酸特拉唑嗪雜質(zhì)B;特拉唑嗪標(biāo)準(zhǔn)品2-R
- CBNumber:
- CB11270410
- 分子式:
- C19H25N5O4
- 分子量:
- 387.43
- MOL File:
- 109351-34-0.mol
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鹽酸特拉唑嗪化學(xué)性質(zhì)
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沸點(diǎn):
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664.5±65.0 °C(Predicted)
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密度:
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1.332±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO: 75 mg/mL (193.58 mM)
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酸度系數(shù)(pKa):
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6.52±0.50(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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鹽酸特拉唑嗪性質(zhì)、用途與生產(chǎn)工藝
(R)-Terazosin 是 Terazosin 的活性 R 型對應(yīng)體, 是一種有效的 α1-腎上腺素受體拮抗劑，對 α1a，α1b 和 α1d-腎上腺素受體的 Ki 值分別為 6.51 nM，1.01 nM 和 1.97 nM。
Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)
(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K
i
values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.
(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.
(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC
30
of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA
2
values of 7.5 and 5.31, respectively.
鹽酸特拉唑嗪
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2024/11/08 | HY-B0371B | 鹽酸特拉唑嗪
(R)-Terazosin | 109351-34-0 | 5mg | 2000元 |
| 2024/11/08 | HY-B0371B | 鹽酸特拉唑嗪
(R)-Terazosin | 109351-34-0 | 10mM * 1mLin DMSO | 2200元 |
109351-34-0, 鹽酸特拉唑嗪 相關(guān)搜索:
- 抑制劑
- 雜質(zhì)對照品
- 對照品-雜質(zhì)對照品
- (R)-特拉唑嗪
- 鹽酸特拉唑嗪雜質(zhì)B
- 特拉唑嗪標(biāo)準(zhǔn)品2-R
- 109351-34-0
- (R)-Terazosin,α1-adrenoceptor,affinity,inhibit,subtypes,prove,Adrenergic Receptor,(R)Terazosin,Inhibitor,(R) Terazosin,Low,α2-adrenoceptor,Beta Receptor
- Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2R)-tetrahydro-2-furanyl]-
- (R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
- Terazosin-002-R
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI)
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (R)-
- (R)-Terazosin