AZT TRIPHOSPHATE
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- CAS號:
- 92586-35-1
- 英文名:
- 3'-Azido-3'-deoxythymidine-5'-triphosphate
- 英文別名:
- Zidovudinetriphosphate;zidovudine 5'-triphosphate;3′-Azido-ddTTP 100mM Sodium Solution;3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution
- 中文名:
- AZT TRIPHOSPHATE
- 中文別名:
- 化合物 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-TRIPHOSPHATE TRIETHYL AMMONIUM SALT
- CBNumber:
- CB11074197
- 分子式:
- C10H16N5O13P3·xLi
- 分子量:
- 0
- MOL File:
- 92586-35-1.mol
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AZT TRIPHOSPHATE化學(xué)性質(zhì)
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儲存條件:
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Store at -20°C
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溶解度:
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Methanol (Slightly), Water (Slightly)
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形態(tài):
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Sticky Solid
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顏色:
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Off-White
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穩(wěn)定性:
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Hygroscopic
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AZT TRIPHOSPHATE性質(zhì)、用途與生產(chǎn)工藝
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) 是一種 Zidovudine (AZT) 的活性三磷酸酯代謝產(chǎn)物。AZT triphosphate 具有抗逆轉(zhuǎn)錄病毒的活性，并抑制 HIV 復(fù)制。AZT triphosphate 還可抑制 HBV 的 DNA 聚合酶。AZT triphosphate 可激活線粒體介導(dǎo)的凋亡 (apoptosis) 途徑。
HIV
HBV
DNA polymerase
Reactive oxygen species (ROS)
Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts.
AZT TRIPHOSPHATE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
AZT TRIPHOSPHATE
生產(chǎn)廠家
92586-35-1, AZT TRIPHOSPHATE 相關(guān)搜索:
- 抑制劑
- C10H16N5O13P3xLi
- 化合物 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-TRIPHOSPHATE TRIETHYL AMMONIUM SALT
- 92586-35-1
- 3′-Azido-ddTTP 100mM Sodium Solution
- 3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution
- zidovudine 5'-triphosphate
- Zidovudinetriphosphate