FUDAEUIGIJZUAY-UMIRZPQISA-N
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- CAS號:
- 186371-96-0
- 英文名:
- FUDAEUIGIJZUAY-UMIRZPQISA-N
- 英文別名:
- ZK168281;ZK-168281,ZK168281;FUDAEUIGIJZUAY-UMIRZPQISA-N;2-Propenoic acid, 3-[1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]cyclopropyl]-, ethyl ester, (2E)-
- 中文名:
- FUDAEUIGIJZUAY-UMIRZPQISA-N
- 中文別名:
- 化合物 T13404;化合物 ZK168281
- CBNumber:
- CB03566499
- 分子式:
- C32H46O5
- 分子量:
- 510.7
- MOL File:
- 186371-96-0.mol
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FUDAEUIGIJZUAY-UMIRZPQISA-N化學性質(zhì)
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沸點:
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652.9±55.0 °C(Predicted)
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密度:
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1.15±0.1 g/cm3(Predicted)
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儲存條件:
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4°C, protect from light, stored under nitrogen
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酸度系數(shù)(pKa):
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14.29±0.20(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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FUDAEUIGIJZUAY-UMIRZPQISA-N性質(zhì)、用途與生產(chǎn)工藝
ZK168281 是一種 1α,25(OH)2D3 類似物，也是一種純 VDR 拮抗劑，Kd 值為 0.1 nM。ZK168281 是其受體 CoA 相互作用的有效抑制劑。
ZK168281 resembles more the mouse constitutive androstane receptor (CAR) inverse agonist Androstanol in its ability to recruit corepressor (CoR) proteins. A salt bridge between the CoR and a conserved lysine in helix 4 of the nuclear receptor (NR) is central to this interaction, but also helix 12 was stabilized by direct contacts with residues of the CoR. Fixation of helix 12 in the antagonistic/inverse agonistic conformation prevents an energetically unfavorable free floatation of the C terminus.
FUDAEUIGIJZUAY-UMIRZPQISA-N
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2024/11/08 | HY-12407 | FUDAEUIGIJZUAY-UMIRZPQISA-N
ZK168281 | 186371-96-0 | 1mg | 8500元 |
FUDAEUIGIJZUAY-UMIRZPQISA-N
生產(chǎn)廠家
186371-96-0, FUDAEUIGIJZUAY-UMIRZPQISA-N 相關搜索:
- 抑制劑
- 化合物 ZK168281
- 化合物 T13404
- 186371-96-0
- 2-Propenoic acid, 3-[1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]cyclopropyl]-, ethyl ester, (2E)-
- ZK-168281,ZK168281
- ZK168281
- FUDAEUIGIJZUAY-UMIRZPQISA-N