(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮性質(zhì)、用途與生產(chǎn)工藝

化學(xué)性質(zhì)

(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮是一種環(huán)庚酮并吡啶有機(jī)化合物，其結(jié)構(gòu)中有一個(gè)被硅基單元保護(hù)的活性羥基反應(yīng)，可在酸性條件下進(jìn)行水解反應(yīng)將硅基保護(hù)基脫除。此外，其結(jié)構(gòu)中含有一個(gè)羰基α碳原子手性中心，它對(duì)堿性物質(zhì)較為敏感，容易在堿的作用下發(fā)生烯醇式互變異構(gòu)導(dǎo)致其手性消失。

用途

(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮是一種醫(yī)藥化學(xué)中間體，它可用于藥物分子瑞美吉泮的生產(chǎn)。

(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮 生產(chǎn)廠家

 

1190363-46-2, (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮 相關(guān)搜索:

• 1190363-46-2
• 雜質(zhì)對(duì)照品
• 化學(xué)試劑
• 化工原料及中間體
• 醫(yī)藥化工
• 化工品
• C25H33F2NO2Si
• (6S,9R)-6-(2,3-氟苯基)-6,7,8,9-四氫 9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮
• 瑞美吉泮中間體1
• 瑞美吉泮雜質(zhì)14
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基
• 9-((三異丙基硅基)OXY)-6,7,8,9-四氫-5H環(huán)己二[B]吡啶-5-酮鹽酸鹽
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三(1-甲基乙基)甲硅烷基]氧基]-5H-環(huán)庚并[B]吡啶-5-酮(化合物9A)
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]環(huán)庚三烯并[B]吡啶-5-酮
• 瑞美吉泮雜質(zhì)8
• (6S,9R)-6-(2,3-二氟苯基)-9 -((三異丙基硅基)氧基)-6,7,8,9-四氫-5H-環(huán)庚并[B]吡啶-5-酮
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮(瑞美吉泮中間體)
• 瑞美吉泮中間體7
• 瑞美吉泮中間體2
• BMS-846372雜質(zhì)1
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[(三異丙基硅)氧基]-5H-環(huán)庚[B]吡啶-5-酮
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-氧基-5H-環(huán)庚并[B]吡啶-5-酮
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三(1-甲基乙基)甲硅烷基]氧基]-5H-環(huán)庚并[B]吡啶-5-酮
• (6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮
• 1190363-46-2
• Ramazepam Impurity 8
• Rimegepant Impurity 14
• (6S, 9R) -6- (2,3-fluorophenyl) -6,7,8,9-tetrahydro-9- [[[triisopropylsilyl] oxy] -5H-cyclohepteno [B] pyridin-5-one
• (6S,9R)-6-(2,3-difluorophenyl)-9-{[tris(propan-2-yl)silyl]oxy}-5H,6H,7H,8H,9H-cyclohepta[b]pyridin-5-one
• 9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one hydrochloride
• (6R,9S)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro- 9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one
• (6S,9R)-6- (2,3-Difuorophenyl)-6.7,8.9-tetrahydro-9 [[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin 5-0n?
• Rimegepant Impurity 8
• (6S,9R)-6-(2,3-Difluoroph
• 5H-Cyclohepta[b]pyridin-5-one, 6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-, (6S,9R)-
• ERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE
• EOS-60325
• (6S,9R)-6-(2,3-difluorophenyl)-9-tri(propan-2-yl)silyloxy-6,7,8,9-tetrahydrocyclohepta[b]pyridin-5-one
• 5H-Cyclohepta[b]pyridin-5-one, 6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-
• BMS-846372 Impurity 1
• (6S,9R)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one
• (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one