99217-63-7
中文名稱
苦參新醇 A
英文名稱
Leachianone E
CAS
99217-63-7
分子式
C25H28O5
分子量
408.49
MOL 文件
99217-63-7.mol
更新日期
2024/12/25 17:21:35
99217-63-7 結(jié)構(gòu)式
基本信息
中文別名
苦參醇A苦參新醇 A
苦參新醇A對照品
苦參新醇A標準品
英文別名
Kushenol ALeachianone E
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
所屬類別
天然產(chǎn)物：黃酮類化合物物理化學性質(zhì)
熔點175-178 °C
沸點581.7±50.0 °C(Predicted)
密度1.212±0.06 g/cm3(Predicted)
儲存條件4°C, protect from light
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)7.66±0.40(Predicted)
形態(tài)Cryst.
顏色White to off-white
常見問題列表
生物活性
Kushenol A (Leachianone E) 從苦參根中分離出來的。Kushenol A 是一種非競爭性酪氨酸酶 (tyrosinase) 抑制劑，可阻止 L-tyrosinase 轉(zhuǎn)化為 L-DOPA，IC50 和 Ki 值分別為 1.1 μM 和 0.4 μM。Kushenol A 是一種類黃酮抗氧化劑，對 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM; Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被認為是化妝品針對皮膚美白和衰老的潛在酶抑制劑。靶點
IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)
體外研究
Kushenol A (25?μM) exhibits a highly potent inhibitory activity on ABTS+?radical scavenging with an IC 50 value of 9.7?±?0.1?μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25?μM.Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells.
Cell Viability Assay
| Cell Line: | NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B |
| Concentration: | 0-60 μg/ml |
| Incubation Time: | 24 hours |
| Result: | Exhibited considerable cytotoxic effects against NSCLC cells. |