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98625-26-4

中文名稱 (S)-(-)-BAY-K-8644
英文名稱 S(-)-BAY K 8644
CAS 98625-26-4
分子式 C16H15F3N2O4
分子量 356.3
MOL 文件 98625-26-4.mol
更新日期 2024/07/01 17:51:36
98625-26-4 結(jié)構(gòu)式 98625-26-4 結(jié)構(gòu)式

基本信息

中文別名
化合物(S)-(-)-BAY K 8644
(S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氫吡啶-3-甲酸甲酯
英文別名
R-5417
BAY-r-5417
S(-)-BAY K 8644
Bay-K-8644 ((S)-(-)-)
S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO
methyl (-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridine-3-carboxylate
(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
(4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester

物理化學(xué)性質(zhì)

儲(chǔ)存條件2-8°C
溶解度H2O: slightly soluble
溶解度H2O:微溶
形態(tài)solid
顏色yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/38
安全說明26-36
WGK Germany3
WGK Germany3
海關(guān)編碼2933399990

常見問題列表

生物活性
(S)-(-)-Bay-K-8644 是 L 型鈣離子通道激動(dòng)劑。(S)-(-)-Bay-K-8644 激活 Ba2+電流 (IBa),EC50 為 32 nM。
靶點(diǎn)

EC50: 32 nM (I Ba )

體外研究

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca 2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I Ba in gastric myocytes of the guinea pig antrum. The Ca 2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca 2+ channels. The interactions of two Ca 2+ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca 2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC 50 =14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca 2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.

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