98625-26-4
基本信息
(S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氫吡啶-3-甲酸甲酯
BAY-r-5417
S(-)-BAY K 8644
Bay-K-8644 ((S)-(-)-)
S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO
methyl (-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridine-3-carboxylate
(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
(4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester
常見問題列表
EC50: 32 nM (I Ba )
(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca 2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I Ba in gastric myocytes of the guinea pig antrum. The Ca 2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca 2+ channels. The interactions of two Ca 2+ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca 2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC 50 =14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca 2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.