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928659-17-0

中文名稱 Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate
英文名稱 Triazavirin
CAS 928659-17-0
分子式 C5H7N6NaO4S
分子量 270.2
MOL 文件 928659-17-0.mol
更新日期 2024/12/13 09:53:01
928659-17-0 結(jié)構(gòu)式 928659-17-0 結(jié)構(gòu)式

基本信息

中文別名
2-甲硫基-6-硝基-1,2,4-三唑并[5,1c][1,2,3]-三嗪-7-酮鈉鹽二水合物
7-(甲硫基)-3-硝基-[1,2,4]三唑并[5,1-C][1,2,4]三嗪環(huán)-4(6H)-酮鈉鹽二水化合物
英文別名
Triazavirin
Triazavirin (Riamilovir)
Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate
Sodium 7-(methylthio)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-6-ide dihydrate
1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate
所屬類別
原料藥:抗病毒類藥

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度DMSO: 125 mg/mL (436.76 mM)
形態(tài)固體
顏色Light yellow to yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
Triazavirin價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-19743Triazavirin
Triazavirin
928659-17-05mg500元
2024/11/08HY-19743Triazavirin
Triazavirin
928659-17-010mg800元
2024/11/08S6854Triazavirin928659-17-01mg1056.51元

常見問(wèn)題列表

生物活性
Triazavirin (TZV, Riamilovir)是一種新型的抗病毒藥物,一種核酸的 nucleoside analogue,可抑制 synthesis of viral RNA and DNA 以及基因組片段的復(fù)制。Triazavirin 對(duì)流感和許多其他病毒具有活性。Triazavirin 在流感傳播階段可作為有效的保護(hù)性藥劑。
靶點(diǎn)

Nucleoside analogue; Influenza virus

體外研究

The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin ) by accumulation in the SKEV cell culture.

體內(nèi)研究

The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed.

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