92092-36-9
中文名稱
DIPHTHERIA TOXIN
CAS
92092-36-9
基本信息
英文別名
DIPHTHERIA TOXINDiphtheria toxin (CRM197)
DIPHTHERIA TOXIN, CRM MUTANT
CORYNEBACTERIUM DIPHTHERIAE TOXIN
(GLU-52)-DIPHTHERIA TOXIN FROM*CORYNEBAC
(glu52)-diphtheria toxin from*corynebacterium dip
Diphtheria Toxin from Corynebacterium diphtheriae
Diphtheria toxin[Glu-52], Corynebacterium diphtheriae
DIPHTHERIA TOXIN, UNNICKED, CORYNEBACTERIUM DIPHTHERIAE
[glu52]-diphtheria toxin from corynebacterium diphtheriae
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H300+H330
防范說(shuō)明P301+P310+P330-P304+P340+P310
危險(xiǎn)品標(biāo)志T+
危險(xiǎn)類別碼28
安全說(shuō)明22-24/25-45-36/37-28
危險(xiǎn)品運(yùn)輸編號(hào)3172
WGK Germany3
RTECS號(hào)XW5807200
危險(xiǎn)等級(jí)6.1(a)
包裝類別I
常見(jiàn)問(wèn)題列表
生物活性
Diphtheria toxin CRM197 是白喉毒素的一個(gè)無(wú)毒變種，具有一個(gè)單一的突變 (52 位的甘氨酸到谷氨酸的替代)，可以消除其毒性。CRM197 作為載體蛋白廣泛應(yīng)用于疫苗中。體外研究
Diphtheria toxin CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally against Haemophilus influenzae, pneumococcus, and meningococcus.
Diphtheria toxin, a single polypeptide secreted by lysogenic strains of
Corynebacterium diphtheria
, causes the disease diphtheria in humans by gaining entry into the cytoplasm of cells and inhibiting protein synthesis.