912-60-7
912-60-7 結(jié)構(gòu)式
基本信息
鹽酸那可汀
鹽酸那可丁
那可丁鹽酸鹽
那可汀鹼鹽酸鹽
那可汀 鹽酸鹽
那可汀鹽酸鹽水合物
那可丁鹽酸鹽水合物
那可丁鹽酸鹽一水合物
諾司卡品 鹽酸鹽 水合物
opianhydrochloride
capvalhydrochloride
lyobexhydrochloride
nsc5366hydrochloride
vadebexhydrochloride
NOSCAPINE BASE / HCL
coscopinhydrochloride
longatinhydrochloride
nectadonhydrochloride
物理化學(xué)性質(zhì)
常見問題列表
Sigma opioid receptors Bradykinin Apoptosis
Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC
50
of 250 μM at 72 hours.
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.
Cell Proliferation Assay
| Cell Line: | Rat C6 glioma cells |
| Concentration: | 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM |
| Incubation Time: | 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours |
| Result: | Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. |
Noscapine (300?mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells |
| Dosage: | 300?mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume. |