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905585-60-6

英文名稱 3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]-
CAS 905585-60-6
分子式 C20H20F2N6O
分子量 398.41
MOL 文件 905585-60-6.mol
905585-60-6 結構式 905585-60-6 結構式

基本信息

英文別名
3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]-

應用領域

用途一
AZD6918 is a novel potent and selective inhibitor of the Trk tyrosine kinases. AZD-6918 attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. AZD6918 inhibited wild-type TrkB-induced cell migration and cell growth.
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