904763-27-5

基本信息
ATN 161 TFA salt
ATN-161 TFA salt
ATN-161 Trifluoroacetate
ATN-161 trifluoroacetate salt
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2025/02/08 | HY-13535A | 904763-27-5 ATN-161 trifluoroacetate salt | 904763-27-5 | 2 mg | 800元 |
2025/02/08 | HY-13535A | 904763-27-5 ATN-161 trifluoroacetate salt | 904763-27-5 | 5mg | 1100元 |
2025/02/08 | HY-13535A | 904763-27-5 ATN-161 trifluoroacetate salt | 904763-27-5 | 10mg | 1600元 |
常見(jiàn)問(wèn)題列表
Integrin α5β1
The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03). ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group).
The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564.