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904763-27-5

中文名稱(chēng) 904763-27-5
英文名稱(chēng) ATN 161 TFA salt
CAS 904763-27-5
分子式 C25H36F3N9O10S
分子量 711.668
MOL 文件 904763-27-5.mol
更新日期 2024/11/15 18:20:32
904763-27-5 結(jié)構(gòu)式 904763-27-5 結(jié)構(gòu)式

基本信息

中文別名
化合物ATN-161 TRIFLUOROACETATE SALT
英文別名
ATN161 TFA salt
ATN 161 TFA salt
ATN-161 TFA salt
ATN-161 Trifluoroacetate
ATN-161 trifluoroacetate salt

物理化學(xué)性質(zhì)

熔點(diǎn)>229°C (dec.)
儲(chǔ)存條件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度可微溶于水(微溶、加熱、超聲處理)
形態(tài)固體
顏色白色至灰白色
904763-27-5價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/02/08HY-13535A904763-27-5
ATN-161 trifluoroacetate salt
904763-27-52 mg800元
2025/02/08HY-13535A904763-27-5
ATN-161 trifluoroacetate salt
904763-27-55mg1100元
2025/02/08HY-13535A904763-27-5
ATN-161 trifluoroacetate salt
904763-27-510mg1600元

常見(jiàn)問(wèn)題列表

生物活性
ATN-161 trifluoroacetate salt 是一種新型 integrin α5β1 拮抗劑,在肝轉(zhuǎn)移模型小鼠模型中,抑制血管生成。
靶點(diǎn)

Integrin α5β1

體外研究

The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03). ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group).

體內(nèi)研究

The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564.

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