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881851-50-9

中文名稱 H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
英文名稱 Larazotide
CAS 881851-50-9
分子式 C34H59N9O12
分子量 785.885
MOL 文件 881851-50-9.mol
更新日期 2024/12/26 16:27:35
881851-50-9 結(jié)構(gòu)式 881851-50-9 結(jié)構(gòu)式

基本信息

中文別名
LARAZOTIDE ACETATE (>
90%)
英文別名
Larazotide acetate
LARAZOTIDE ACETATE (> 90%)
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
所屬類別
有機(jī)原料：羧酸類化合物及衍生物

物理化學(xué)性質(zhì)

熔點(diǎn)>231°C (dec.)
儲(chǔ)存條件Refrigerator
溶解度可微溶于水
形態(tài)固體
顏色白色
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-91mg700元
2024/11/08HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-95mg1100元
2024/11/08HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-910mM * 1mLin Water1556元

常見(jiàn)問(wèn)題列表

生物活性
Larazotide acetate 是一種合成肽，是一種緊密連接 (junction) 的調(diào)節(jié)劑。
靶點(diǎn)

Paracellular permeability

體外研究

Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.

體內(nèi)研究

When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.

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