879127-16-9
中文名稱
AURORA KINASE INHIBITOR III
英文名稱
Aurora Kinase Inhibitor III
CAS
879127-16-9
分子式
C21H18F3N5O
分子量
413.4
MOL 文件
879127-16-9.mol
更新日期
2024/11/11 15:50:47
879127-16-9 結(jié)構(gòu)式
基本信息
英文別名
AKI-7169Aurora Kinase Inhibitor 3
Aurora Kinase Inhibitor III
AKI-7169(Aurora Kinase Inhibitor III)
Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem
N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide >=98% (HPLC), solid
物理化學(xué)性質(zhì)
密度1.456±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度H2O：<2毫克/毫升
酸度系數(shù)(pKa)14.51±0.70(Predicted)
形態(tài)白色固體
顏色白色
AURORA KINASE INHIBITOR III價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-112373 | AURORA KINASE INHIBITOR III Aurora kinase inhibitor-3 | 879127-16-9 | 1mg | 855元 |
| 2024/11/08 | HY-112373 | AURORA KINASE INHIBITOR III Aurora kinase inhibitor-3 | 879127-16-9 | 5mg | 1500元 |
| 2024/11/08 | HY-112373 | AURORA KINASE INHIBITOR III Aurora kinase inhibitor-3 | 879127-16-9 | 10mM * 1mLin DMSO | 1650元 |
常見(jiàn)問(wèn)題列表
生物活性
Aurora kinase inhibitor III是有效的Aurora A kinase抑制劑，IC50為42 nM。它對(duì)BMX, BTK, IGF-1R, c-Src, TRKB, SYK和EGFR分別為386, 3550, 591, 1980, 2510, 887和>10,000 nM。靶點(diǎn)
| Target | Value |
|
Aurora A
(Cell-free assay) | 42 nM |
|
BMX
(Cell-free assay) | 386 nM |
|
IGF-1R
(Cell-free assay) | 591 nM |
|
SYK
(Cell-free assay) | 887 nM |
|
c-Src
(Cell-free assay) | 1980 nM |