877950-01-1
877950-01-1 結(jié)構(gòu)式
基本信息
化合物L(fēng)TAS-IN-1
(5-phenyl-1,3,4-oxadiazol-2-yl)carbamoyl]methyl 2-{naphtho[2,1-b]furan-1-yl}acetate
2-oxo-2-((5-phenyl-1,3,4-oxadiazole-2-yl)amino-)ethyl 2-(naphtho[2,1-b]furo-1-yl)acetate
Naphtho[2,1-b]furan-1-acetic acid, 2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl ester
Bacterial,MDR,E. faecium,LtaSIN1,multidrug-resistant,inhibit,LtaS IN 1,anti-bacterial,Inhibitor
物理化學(xué)性質(zhì)
常見問題列表
MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590)
LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively.