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871026-18-5

中文名稱(chēng) 2-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy)ethan-1-ol
英文名稱(chēng) 2-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy)ethan-1-ol
CAS 871026-18-5
分子式 C23H20ClF3N4O3
分子量 492.88
MOL 文件 871026-18-5.mol
871026-18-5 結(jié)構(gòu)式 871026-18-5 結(jié)構(gòu)式

基本信息

中文別名
化合物SYR127063
英文別名
185556
BDBM92454
SYR127063
BDBM-92454
BDBM 92454
Ethanol, 2-[2-[4-[[3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl]amino]-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy]-
2-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy)ethan-1-ol

應(yīng)用領(lǐng)域

用途一
SYR127063, also known as BDBM92454, is a potent and selective HER2 inhibitor (IC50 data: HER2 = 11 nM; EGFR = 429 nM; HER4 > 10000 nM). SYR127063 binds to HER2 in an active-like conformation.
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