865783-99-9
中文名稱
BRICICLIB
英文名稱
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)
CAS
865783-99-9
分子式
C19H23O10PS
分子量
474.42
MOL 文件
865783-99-9.mol
更新日期
2024/11/08 11:24:22
865783-99-9 結(jié)構(gòu)式
基本信息
中文別名
布瑞西利布瑞西利, >98%
化合物BRICICLIB
BRICICLIB (SYNONYMS: ON 014185)
英文別名
CS-2580ON-014185
Briciclib, >98%
Briciclib,ON-014185
Briciclib(ON 013105,ON 014185)
ON013105
ON014185
ON-013105
ON-014185
(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate
2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white
BRICICLIB價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | S6533 | BRICICLIB Briciclib | 865783-99-9 | 2mg | 795.41元 |
| 2023/03/20 | XW86578399903 | 布瑞西利 | 865783-99-9 | 5MG | 240元 |
| 2023/03/20 | XW86578399902 | 布瑞西利 | 865783-99-9 | 25MG | 727元 |
常見問題列表
生物活性
Briciclib (ON-014185)是ON-013100的水溶性衍生物。ON-013100是一種可與eIF4E結(jié)合并抑制其活性的小分子化合物。靶點(diǎn)
eIF4E
體外研究
Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI 50 s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.