861214-33-7
中文名稱
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
英文名稱
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
CAS
861214-33-7
分子式
C16H10FN3O2
分子量
295.27
MOL 文件
861214-33-7.mol
更新日期
2023/03/20 15:41:21
861214-33-7 結(jié)構(gòu)式
基本信息
中文別名
化合物5'-FLUOROINDIRUBINOXIME5'-氟-3-(肟基)-[2,3'-雙吲哚亞基]-2'-酮
英文別名
5'-FIO-Fluoroindirubinoxime
5'-Fluoroindirubinoxime
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-
物理化學性質(zhì)
沸點528.3±50.0 °C(Predicted)
密度1.57±0.1 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO : 83.33 mg/mL (282.22 mM; Need ultrasonic)
酸度系數(shù)(pKa)8.48±0.20(Predicted)
形態(tài)粉末
顏色Light brown to black
常見問題列表
生物活性
5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物，是FLT3 的抑制劑，其IC50 值為15 nM。靶點
15 nM (FLT3).
體外研究
5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC
50
values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC
50
values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.
體內(nèi)研究
5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.
| Animal Model: | Rat tumor model based RK3E-ras cells. |
| Dosage: | S.C.. |
| Administration: | 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. |
| Result: | Effectively inhibited tumor growth. |