85187-37-7
基本信息
氯哌斯汀芬地柞酸鹽
氯芐哌醚聯(lián)苯酰苯酸鹽
Cloperastine fendizoate
Cloperastine Febdizoate
Levocloperastine Fendizoate
Levocloperastine Fendizoate Racemic Impurity
1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) ISO 9001:2015 REACH
物理化學(xué)性質(zhì)
報(bào)價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-B2179 | 氯芐哌醚聯(lián)苯酰苯酸鹽 Cloperastine fendizoate | 85187-37-7 | 500mg | 500元 |
2024/11/08 | HY-B2179 | 氯芐哌醚聯(lián)苯酰苯酸鹽 Cloperastine fendizoate | 85187-37-7 | 10mM * 1mLin DMSO | 550元 |
常見問題列表
27 nM (K + currents)
Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with IC 50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.