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85187-37-7

中文名稱 氯芐哌醚聯(lián)苯酰苯酸鹽
英文名稱 o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
CAS 85187-37-7
分子式 C40H38ClNO5
分子量 648.186
MOL 文件 85187-37-7.mol
85187-37-7 結(jié)構(gòu)式 85187-37-7 結(jié)構(gòu)式

基本信息

中文別名
氯哌斯汀芬地柞酸
氯哌斯汀芬地柞酸鹽
氯芐哌醚聯(lián)苯酰苯酸鹽
英文別名
Cloperastine fendiz
Cloperastine fendizoate
Cloperastine Febdizoate
Levocloperastine Fendizoate
Levocloperastine Fendizoate Racemic Impurity
1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) ISO 9001:2015 REACH
所屬類別
醫(yī)藥中間體:原料藥中間體

物理化學(xué)性質(zhì)

熔點(diǎn)185-187°C
儲存條件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度可溶于DMSO(少許)、甲醇(少許)
形態(tài)固體
顏色白色至灰白色
穩(wěn)定性吸濕性

安全數(shù)據(jù)

危險性描述H412
防范說明P273-P501
氯芐哌醚聯(lián)苯酰苯酸鹽價格(試劑級)
報(bào)價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-B2179氯芐哌醚聯(lián)苯酰苯酸鹽
Cloperastine fendizoate
85187-37-7500mg500元
2024/11/08HY-B2179氯芐哌醚聯(lián)苯酰苯酸鹽
Cloperastine fendizoate
85187-37-710mM * 1mLin DMSO550元

常見問題列表

生物活性
Cloperastine fendizoate 抑制 hERG K+ 電流,IC50 為 27 nM,這種作用具有濃度依賴性。
靶點(diǎn)

27 nM (K + currents)

體外研究

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with IC 50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

體內(nèi)研究

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

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