83654-05-1
83654-05-1 結(jié)構(gòu)式
基本信息
Rg 80267
RHC-80267
RXSVYGIGWRDVQC-UHFFFAOYSA-N
RHC-80267 - CAS 83654-05-1 - Calbiochem
1,6-bis(cyclohexyloximinocarbonyl)hexane
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908
O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone
物理化學性質(zhì)
常見問題列表
1,6-雙(環(huán)己基脒基羰基氨基)己烷可抑制多種細胞類型和組織中的DAG 脂肪酶活性，包括犬血小板、牛腎上腺嗜鉻細胞、人腎上腺腎小球細胞、大鼠甲狀腺葉和胰腺小葉。 犬血小板中的 IC50 為 4 μM。
| Target | Value |
|
cholinesterase
(Cell-free assay) | 4 μM |
The potentiation by RHC 80267 of the relaxation to acetylcholine could be caused by the inhibition of cholinesterase: (1) RHC 80267 does not affect the responses to carbachol, the carbamyl derivative of acetylcholine which only differs from acetylcholine by its resistance to hydrolysis by cholinesterase, and (2) the effect of RHC 80267 is mimicked by the inhibitor of cholinesterase neostigmine, RHC 80267 showing no additional effect in the presence of a maximally effective concentration of neostigmine. The determination of the effect of RHC 80267 on the cholinesterase activity of brain homogenate confirmed that RHC 80267 inhibits this enzyme in the same range of concentrations increasing the relaxation to acetylcholine, namely at 1-10 μM.
RHC 80267 (40 μM) enhances contractions induced by U46619 (a thromboxane A2 analog) in human and rat pulmonary arteries (hPAs and rPAs, respectively) and by angiotensin II (ANG II) in rPAs in an endothelium-dependent manner.