828288-98-8
828288-98-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度2.14±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 100 mg/mL (216.73 mM)
酸度系數(shù)(pKa)0.90±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Asp-AMS是天冬氨酸腺苷酸的一個(gè)類似物，是 aspartyl-tRNA 合成酶 (aspartyl-tRNA synthetase) 的一個(gè)抑制劑，也是線粒體酶 (mitochondrial enzyme) 的強(qiáng)效競(jìng)爭(zhēng)性抑制劑。靶點(diǎn)
Aspartyl-tRNA synthetase, Mitochondrial enzyme .
體外研究
Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with K i in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with K i values in the nanomolar range, with a stronger effect on bacterial AspRSs ( E. coli and P. aeruginosa ) than on human cytosolic AspRS.