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82101-17-5

中文名稱 伊普柳氮
英文名稱 ipsalazide
CAS 82101-17-5
MOL 文件 82101-17-5.mol
82101-17-5 結構式 82101-17-5 結構式

基本信息

中文別名
化合物 T19379
英文別名
5-(Carboxymethylcarbamoyl-4-phenylazo)salicylic acid (disodium)
5-[[4-[(Sodiooxycarbonylmethyl)carbamoyl]phenyl]azo]-2-hydroxybenzoic acid sodium salt
Benzoic acid, 5-((4-(((carboxymethyl)amino)carbonyl)phenyl)azo)-2-hydroxy-, disodium salt

物理化學性質

儲存條件-20°C儲存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
Ipsalazide 是一種新的柳氮磺吡啶類似物,旨在釋放胃腸道中的 5-氨基水楊酸和無毒載體分子。
體外研究

Sulfasalazine exerts beneficial effects in colitis by releasing 5-aminosalicylic acid in the colon, but its use can be limited by side effects. Ipsalazide is designed which the sulfapyridine of sulfasalazine has been replaced by carrier molecules.

體內研究

No deaths or visible abnormalities occurrs within 7 days of a single oral dose of ipsalazide (4 g/kg in mice or 2 g/kg in rats). No abnormalities were seen at postmortem. The ipsalazide carrier molecule (ABG) is readily absorbed, with nearly half of the dose appearing in the urine. However, around 40% of the ABG was not recovered, and it is possible that this has undergone further metabolism, with loss of the aromatic amine function which is the basis for the colorimetric measurement of ABG.

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