81424-67-1
81424-67-1 結(jié)構(gòu)式
基本信息
中文別名
卡醋胺 英文別名
CaracemideNSC-253272
N-Acetyl-N-(methylcarbamoyloxy)-N'-methylurea
N-(Methylcarbamoyl)-N-((methylcarbamoyl)oxy)acetamide
物理化學(xué)性質(zhì)
熔點122.25°C
沸點324.41°C (rough estimate)
密度1.4204 (rough estimate)
折射率1.5500 (estimate)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.18±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Caracemide (NSC-253272) 可以抑制大腸桿菌的核糖核苷酸還原酶。Caracemide是衍生自異羥肟酸的新型抗癌藥，會產(chǎn)生嚴(yán)重的中樞神經(jīng)系統(tǒng) (CNS) 毒性。體外研究
Caracemide inactivates R1 by covalent modification at the substrate-binding site and has a toxic metabolite, methylisocyanate (MIC), in vivo.
體內(nèi)研究
The mercapturic acid derivative AMCC was identified in urine rats following administration to rats of a single i.p. dose (6.6 mg/kg) of caracemide (NSC-253272).
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