791835-21-7
791835-21-7 結(jié)構式
基本信息
中文別名
化合物BI-6C9N-(4-((4-氨基苯基)硫代)苯基)-4-(4-甲氧基苯基磺酰胺基)丁酰胺
英文別名
N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamideButanamide, N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-
物理化學性質(zhì)
密度1.36±0.1 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO: 24 mg/mL, soluble
酸度系數(shù)(pKa)11.58±0.50(Predicted)
形態(tài)solid
顏色米白色
常見問題列表
生物活性
BI-6C9 是一種高特異性的 BH3 相互作用結(jié)構域 (Bid) 抑制劑，可阻止線粒體外膜電位 (MOMP) 和線粒體分裂，并保護細胞免受線粒體凋亡誘導因子 (AIF) 釋放和不依賴 caspase 的細胞死亡。體外研究
HT-22 cells shows reduction of cell viability around 4.5 h after Glutamate (3 mM and 5 mM) treatment. BI-6c9 (10 μM; 18 hours) significantly attenuates the loss of cell viability after Glutamate excitotoxicity.
Cell Viability Assay
| Cell Line: | HT-22 cells |
| Concentration: | 10 μM |
| Incubation Time: | 18 hours |
| Result: | Attenuated Glutamate-induced cell death. |