79055-68-8
中文名稱
(R)-(-)-2-氨基-5-膦酰戊酸
英文名稱
D-AP5
CAS
79055-68-8
分子式
C5H12NO5P
分子量
197.13
MOL 文件
79055-68-8.mol
更新日期
2023/12/05 18:21:37
79055-68-8 結(jié)構(gòu)式
基本信息
中文別名
(R)-(-)-2-氨基-5-膦酰戊酸 英文別名
D-AP5D-APV
IF4G2
EIF4G2
(R)-AP-5
Death associated protein 5
D-2-AMINO-5-PHOSPHONOPENTANOIC ACID
(R)-5-Phosphono-2-aminovaleric acid
(R)-2-Amino-5-phosphonovaleric acid
(2R)-2-Amino-5-phosphonovaleric acid
物理化學(xué)性質(zhì)
熔點approximate 233℃
熔點approximate 233℃
沸點482.1±55.0 °C(Predicted)
密度1.529±0.06 g/cm3(Predicted)
RTECS號RD2513000
儲存條件Store at RT
溶解度Soluble to 100 mM in sterile
酸度系數(shù)(pKa)2.46±0.10(Predicted)
形態(tài)白色固體
顏色白色
水溶解性Soluble in water (100mM)
敏感性感光
常見問題列表
生物活性
D-AP5 (D-APV) 是一種選擇性和競爭性 NMDA 受體拮抗劑，Kd 為 1.4 μM。D-AP5 抑制 NMDA 受體的谷氨酸結(jié)合位點。靶點
NMDA
體內(nèi)研究
D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP)
in vivo
. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented.
D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze.