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76263-13-3

中文名稱 氟齊胺
英文名稱 Fluzinamide
CAS 76263-13-3
分子式 C12H13F3N2O2
分子量 274.24
MOL 文件 76263-13-3.mol
76263-13-3 結(jié)構(gòu)式 76263-13-3 結(jié)構(gòu)式

基本信息

中文別名
氟齊胺
氟澤酰胺
英文別名
AHR-8559
Fluzinamide
3-[3-(Trifluoromethyl)phenoxy]-1-(methylcarbamoyl)azetidine
1-Azetidinecarboxamide, N-methyl-3-[3-(trifluoromethyl)phenoxy]-

物理化學性質(zhì)

沸點415.7±45.0 °C(Predicted)
密度1.337±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)14.24±0.40(Predicted)

常見問題列表

生物活性
Fluzinamide 是一種有效的抗癲癇劑。
體內(nèi)研究

Fluzinamide, an antiepileptic agent effective against partial seizures, is metabolized extensively in mice, rats and dogs.The anticonvulsant properties of Fluzinamide (AHR-8559) are evaluated in the kindled amygdaloid seizure model in rats. Fluzinamide significantly attenuates afterdischarge durations and the severity of the accompanying convulsive responses in previously kindled rats at doses that does not cause sedation or ataxia. After acute intraperitoneal injections, the maximum anticonvulsant effectiveness against suprathreshold (400 μA) stimulation is seen at 30 min. Fluzinamide (10-80 mg/kg i.p.) is also evaluated in kindled rats using threshold (20 μA increments) seizures. Low doses of Fluzinamide significantly elevate seizure threshold and reduce both elicited after discharge durations and seizure severity. When administered daily during kindling acquisition, Fluzinamide (20 and 40 mg/kg i.p.) significantly increases the number of trials necessary to complete kindling. The duration and the severity of the responses induced by stimulations during the acquisition period are reduced.

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