761438-38-4
中文名稱
2-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]-N-甲基苯磺酰胺
英文名稱
ALK inhibitor 2
CAS
761438-38-4
分子式
C23H28ClN7O3S
分子量
518.03
MOL 文件
761438-38-4.mol
更新日期
2024/11/06 10:09:16
761438-38-4 結(jié)構(gòu)式
基本信息
中文別名
化合物ALK INHIBITOR 2ALK抑制劑(ALK INHIBITOR 2)
2-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]-N-甲基苯磺酰胺
英文別名
ALK inhibitor 22-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-
2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide
2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide
2-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide
BenzenesulfonaMide, 2-[[5-chloro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl-
物理化學(xué)性質(zhì)
沸點(diǎn)712.4±70.0 °C(Predicted)
密度1.371±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.27±0.10(Predicted)
形態(tài)粉末
顏色White to gray
常見(jiàn)問(wèn)題列表
生物活性
ALK inhibitor 2 (compound 18) 是一種有效的，嘧啶類 ALK 抑制劑。ALK inhibitor 2 是有效的睪丸特異性絲氨酸/蘇氨酸激酶 2 (TSSK2; IC50=37 nM) 和粘著斑激酶 (FAK; IC50=5 nM) 抑制劑。靶點(diǎn)
IC50: 37 nM (TSSK2) and 5 nM (FAK)
體外研究
Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. ALK inhibitor 2 (compound 18) contains a methylpiperazine A ring (R1=Me, X=N) and a D ring with R5=methylsulfonamide. ALK inhibitor 2 can undergo metabolic oxidation to form reactive adducts in the presence of glutathione.