76-78-8
中文名稱
苦木素
英文名稱
QUASSIN
CAS
76-78-8
分子式
C22H28O6
分子量
388.45
MOL 文件
76-78-8.mol
更新日期
2024/11/07 16:36:59
76-78-8 結(jié)構(gòu)式
基本信息
中文別名
苦味素苦木素
QUASSIN (~90%)
QUASSIN (>
95%)
英文別名
BalsamQUASSIN
Nsc 36342
Alloquassin
4-epiquassin
Quassin (>
QUASSINPOWDER
Quassin (~90%)
Quassin (>95%)
Einecs 200-985-9
所屬類別
天然產(chǎn)物：萜類物理化學(xué)性質(zhì)
熔點(diǎn)222°
比旋光度D20 +34.5° (c = 5.09 in CHCl3)
沸點(diǎn)586.3±50.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C Freezer, Under inert atmosphere
溶解度可溶于氯仿（少許）、甲醇（少許）
形態(tài)固體
顏色白色至灰白色
LogP2.220 (est)
EPA化學(xué)物質(zhì)信息Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- (76-78-8)
應(yīng)用領(lǐng)域
用途1
Quassin is a naturally occurring extract from quassia trees and is used in traditional chinese medicine for it鈥檚 antiulcerogenic properties. Quassin have also been used as an additive in soft drinks.苦木素價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-N1581 | 苦木素 Quassin | 76-78-8 | 1mg | 900元 |
| 2024/11/08 | HY-N1581 | 苦木素 Quassin | 76-78-8 | 5mg | 3600元 |
| 2023/03/20 | HY-N1581 | 苦木素 Quassin | 76-78-8 | 10mg | 9800元 |
常見問題列表
生物活性
Quassin (Nigakilactone D) 是一種從 Quassia amara 的莖皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum，IC50 為 0.15 μM。Quassin 具有可逆的抗生育能力，抗雌激素和抗瘧原蟲活性。靶點(diǎn)
IC50: 0.15 μM ( P. falciparum )
體外研究
Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion.
體內(nèi)研究
Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats.
| Animal Model: | 35 females albino rats (150-170 g) |
| Dosage: | 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg |
| Administration: | Oral administration; daily; for 60 days |
| Result: | There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. |