72734-63-5
72734-63-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15042 英文別名
D 23432-[[3-(2-Methoxyphenyl)-1,1-dimethylpropyl]amino]-1-(p-hydroxyphenyl)ethanol
Benzenemethanol, 4-hydroxy-α-[[[3-(2-methoxyphenyl)-1,1-dimethylpropyl]amino]methyl]-
常見問題列表
生物活性
D2343 是一種 β2 腎上腺素能受體激動劑，也是一種 α1-腎上腺素能受體抑制劑。靶點
β2-adrenoceptor
α1- adrenoceptor
體外研究
D2343 is a compound with about the same beta 2-adrenoceptor-agonist effect as Terbutaline and exhibiting in addition an alpha 1-receptor inhibitory activity. The beta 2-agonistic and alpha 1-antagonistic drug D2343 inhibits the evoked contractions in a concentration related fashion with 50% effect at 9.6 μM.
體內(nèi)研究
D2343 has been compared to the beta 2-agonist Terbutaline on oestrogenized uterine preparations from rat and rabbit and in myometrial strips from homo. D2343 has shown an ability to relax the uterine muscles to the same degree as Terbutaline or even more, especially when the two drugs are compared in preparations from rabbit and rat.