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7266-47-9

中文名稱 ACTH (1-17)
英文名稱 ACTH (1-17)
CAS 7266-47-9
分子式 C95H145N29O23S
分子量 2093.41
MOL 文件 7266-47-9.mol
更新日期 2024/11/03 16:22:39
7266-47-9 結構式 7266-47-9 結構式

基本信息

中文別名
促腎上腺皮質激素片段 (1-17),人
ALPHA1-17-促腎上腺皮質激素
ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-17 HUMAN
ACTH (1-17)
HUMAN
英文別名
ACTH (1-17)
SYSMEHFRWGKPVGKKR
ACTH (1-17), HUMAN
ALPHA 1-17-CORTICOTROPIN
alpha1-17-ACTH
ADRENOCORTICOTROPIC HORMONE (1-27)
alpha1-17-Corticotropin
ADRENOCORTICOTROPIC HORMONE (1-17), HUMAN
ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-17
ADRENOCORTICOTROPIC HORMONE HUMAN FRAGMENT 1-17

物理化學性質

密度1.48±0.1 g/cm3(Predicted)
RTECS號GM7907000
儲存條件−20°C

安全數(shù)據(jù)

WGK Germany3
ACTH (1-17)價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2023/03/20HY-P1545ACTH (1-17)
ACTH (1-17)
7266-47-91mg1300元
2023/03/20HY-P1545ACTH (1-17)
ACTH (1-17)
7266-47-95mg4500元
2023/03/20HY-P1545ACTH (1-17)
ACTH (1-17)
7266-47-910mg6500元

常見問題列表

生物活性
ACTH (1-17) 是促腎上腺皮質激素類似物,是一種有效的人黑皮素受體 (human melanocortin 1 (MC1) receptor) 激動劑,Ki 值為0.21 nM。
靶點

Ki: 0.21 nM (human MC1 receptor)

體外研究

ACTH (1-17) is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a K i value of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures.

體內研究

Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier.

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