691868-88-9
691868-88-9 結(jié)構(gòu)式
基本信息
2-(2,4-二(三氟甲基)咪唑并[1,2-A][1,8]萘啶-8-基)-1,3,4-惡二唑
8-(1,3,4-噁二唑-2-基)-2,4-雙(三氟甲基)咪唑并[1,2-Α][1,8]萘啶
8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
Imidazo[1,2-a][1,8]naphthyridine, 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-
物理化學(xué)性質(zhì)
常見問題列表
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JAK1
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IFNAR2
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RO8191 (CDM-3008) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice.
RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells.
RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B.
RO8191 (CDM-3008; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice.