68027-15-6
68027-15-6 結(jié)構(gòu)式
基本信息
白頭翁皂苷 D, BR
常春藤皂苷元3-O-Α-L-吡喃鼠李糖-(1→2)-Β-D-吡喃葡萄糖-(1→4)-Α-L-吡喃阿拉伯糖苷
Pulsatilla Saponin D (90%)
Pulsatilla saponin D (SB365)
Pulsatilla saponin D 68027-15-6
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)-
Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)-
物理化學(xué)性質(zhì)
常見問題列表
| Target | Value |
|
c-Met
() |
Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase.
Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells.
Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) .
Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.
Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells.
Cell Cytotoxicity Assay
| Cell Line: | A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells. |
| Concentration: | 0.3 ng/mL to 10 μg/mL. |
| Incubation Time: | 72 h. |
| Result: | Exhibited an ED 50 value of 6.3 μg/mL for A-549 cells. |
Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model.
| Animal Model: | 2x2x2 mm 3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice. |
| Dosage: | 6.4 mg/kg. |
| Administration: | Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. |
| Result: | Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). |