664334-36-5
中文名稱
BKT140
英文名稱
BL-8040
CAS
664334-36-5
分子式
C97H144FN33O19S2
分子量
2159.52
MOL 文件
664334-36-5.mol
更新日期
2024/12/31 13:25:38
664334-36-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T14665 英文別名
BKT140BL-8040
TF14016
BKT140, >99%
Motixafortide
BKT140 (BL-8040)
4F-Benzoyl-TN14003
BKT140CXCR4 antagonist
BKT140 4-fluorobenzoyl
MOTIXAFORTIDE
BL-8040
TF14016
物理化學(xué)性質(zhì)
密度1.52±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度≥216 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic; ≥52.4 mg/mL in H2O
形態(tài)結(jié)晶固體
顏色White to off-white
BKT140價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | S9665 | BKT140 Motixafortide (BL-8040) | 664334-36-5 | 5mg | 3600.13元 |
| 2024/11/08 | S9665 | BKT140 Motixafortide (BL-8040) | 664334-36-5 | 25mg | 7770元 |
| 2024/11/08 | S9665 | Motixafortide (BL-8040) | 664334-36-5 | 100mg | 15700元 |
常見問題列表
生物活性
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) 是一種 CXCR4 的拮抗劑，IC50值約為1 nM。BL-8040 通過改變的miR-15a/16-1的表達(dá)，下調(diào) ERK、BCL-2、MCL-1 和 cyclin-D1，誘導(dǎo)AML胚的凋亡。靶點
| Target | Value |
|
ERK
() | |
|
Bcl-2
() | |
|
MCL-1
() | |
|
cyclin-D1
() | |
|
CXCR4
(Cell-free assay) | 1 nM |
體外研究
Motixafortide (BKT140) displays selective toxicity toward AmL and MM cells. Treatment with Motixafortide (BKT140) can overcome IL-6 dependent proliferation and survival of ARH77 MM cells. Motixafortide (BKT140) specifically triggers CXCR4-dependent cell death in leukemia and MM cells. Motixafortide (BKT140) stimulates apoptotic cell death in leukemia and MM cells.
體內(nèi)研究
Subcutaneous injections of Motixafortide (BKT140) significantly reduces, in a dose-dependent manner, the growth of human acute myeloid leukemia and multiple myeloma xenografts. Tumors from animals treated with Motixafortide (BKT140) are smaller in size and weights, had larger necrotic areas and high apoptotic scores.